Abstract
A series of heterocycle-substituted acetophenones were prepared and reacted with the Brønsted superacid CF3SO3H (triflic acid=trifluoromethanesulfonic acid). Cyclodehydration provided aryl-substituted imidazo[2,1-a]isoquinolines and related products (28-85%, seven examples). A mechanism is proposed involving dicationic intermediates.
Original language | English (US) |
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Pages (from-to) | 1457-1461 |
Number of pages | 5 |
Journal | Helvetica Chimica Acta |
Volume | 96 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2013 |
Externally published | Yes |
Keywords
- Cyclodehydration
- Imidazo[2,1-a]isoquinoline
- Superacids