1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain

Petr Bednarik; Dario Goranovic; Alena Svatkova; Fabian Niess; Lukas Hingerl; Bernhard Strasser; Dinesh K. Deelchand; Benjamin Spurny-Dworak; Martin Krssak; Siegfried Trattnig; Gilbert Hangel; Thomas Scherer; Rupert Lanzenberger; Wolfgang Bogner

doi:10.1038/s41551-023-01035-z

¹H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain

Petr Bednarik, Dario Goranovic, Alena Svatkova, Fabian Niess, Lukas Hingerl, Bernhard Strasser, Dinesh K. Deelchand, Benjamin Spurny-Dworak, Martin Krssak, Siegfried Trattnig, Gilbert Hangel, Thomas Scherer, Rupert Lanzenberger, Wolfgang Bogner

Center for Magnetic Resonance Research

Research output: Contribution to journal › Article › peer-review

Abstract

Impaired glucose metabolism in the brain has been linked to several neurological disorders. Positron emission tomography and carbon-13 magnetic resonance spectroscopic imaging (MRSI) can be used to quantify the metabolism of glucose, but these methods involve exposure to radiation, cannot quantify downstream metabolism, or have poor spatial resolution. Deuterium MRSI (²H-MRSI) is a non-invasive and safe alternative for the quantification of the metabolism of ²H-labelled substrates such as glucose and their downstream metabolic products, yet it can only measure a limited number of deuterated compounds and requires specialized hardware. Here we show that proton MRSI (¹H-MRSI) at 7 T has higher sensitivity, chemical specificity and spatiotemporal resolution than ²H-MRSI. We used ¹H-MRSI in five volunteers to differentiate glutamate, glutamine, γ-aminobutyric acid and glucose deuterated at specific molecular positions, and to simultaneously map deuterated and non-deuterated metabolites. ¹H-MRSI, which is amenable to clinically available magnetic-resonance hardware, may facilitate the study of glucose metabolism in the brain and its potential roles in neurological disorders.

Original language	English (US)
Journal	Nature Biomedical Engineering
DOIs	https://doi.org/10.1038/s41551-023-01035-z
State	Accepted/In press - 2023

Bibliographical note

Funding Information:
We thank P. Bolan of the Center for Magnetic Resonance Research, University of Minnesota, and C. Rogers, University of Cambridge, for providing a tool to store and apply 7 T B-shims for the 7 T MR scanner; V. Mlynarik for helpful discussions; and the study participants whose help is greatly appreciated. P.B. was supported by the European Union’s Horizon 2020 research and innovation programme under a Marie Skłodowska-Curie grant (agreement no. 846793), and by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (no. 27238). A.S. received funding from the European Union’s Horizon 2020 research and from an innovation programme under a Marie Skłodowska-Curie grant (agreement no. 794986). The authors acknowledge support from the Austrian Science Fund (FWF) (grants P 30701 and KLI 718 to W.B., I 6037 to B.S., KLI 782 to T.S., and KLI 646 to G.H.). W.B. acknowledges the support of the following NIH grant: R01EB031787. D.K.D. acknowledges support from the following National Institutes of Health grants: BTRC P41 EB027061 and P30 NS076408 0

Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature Limited.

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Publisher link

10.1038/s41551-023-01035-z

Cite this

Bednarik, P., Goranovic, D., Svatkova, A., Niess, F., Hingerl, L., Strasser, B., Deelchand, D. K., Spurny-Dworak, B., Krssak, M., Trattnig, S., Hangel, G., Scherer, T., Lanzenberger, R., & Bogner, W. (Accepted/In press). ¹H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-023-01035-z

Bednarik, P, Goranovic, D, Svatkova, A, Niess, F, Hingerl, L, Strasser, B, Deelchand, DK, Spurny-Dworak, B, Krssak, M, Trattnig, S, Hangel, G, Scherer, T, Lanzenberger, R & Bogner, W 2023, '¹H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain', Nature Biomedical Engineering. https://doi.org/10.1038/s41551-023-01035-z

@article{da270049ac354b06878a36e4ce1f5808,

title = "1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain",

abstract = "Impaired glucose metabolism in the brain has been linked to several neurological disorders. Positron emission tomography and carbon-13 magnetic resonance spectroscopic imaging (MRSI) can be used to quantify the metabolism of glucose, but these methods involve exposure to radiation, cannot quantify downstream metabolism, or have poor spatial resolution. Deuterium MRSI (2H-MRSI) is a non-invasive and safe alternative for the quantification of the metabolism of 2H-labelled substrates such as glucose and their downstream metabolic products, yet it can only measure a limited number of deuterated compounds and requires specialized hardware. Here we show that proton MRSI (1H-MRSI) at 7 T has higher sensitivity, chemical specificity and spatiotemporal resolution than 2H-MRSI. We used 1H-MRSI in five volunteers to differentiate glutamate, glutamine, γ-aminobutyric acid and glucose deuterated at specific molecular positions, and to simultaneously map deuterated and non-deuterated metabolites. 1H-MRSI, which is amenable to clinically available magnetic-resonance hardware, may facilitate the study of glucose metabolism in the brain and its potential roles in neurological disorders.",

author = "Petr Bednarik and Dario Goranovic and Alena Svatkova and Fabian Niess and Lukas Hingerl and Bernhard Strasser and Deelchand, {Dinesh K.} and Benjamin Spurny-Dworak and Martin Krssak and Siegfried Trattnig and Gilbert Hangel and Thomas Scherer and Rupert Lanzenberger and Wolfgang Bogner",

note = "Funding Information: We thank P. Bolan of the Center for Magnetic Resonance Research, University of Minnesota, and C. Rogers, University of Cambridge, for providing a tool to store and apply 7 T B-shims for the 7 T MR scanner; V. Mlynarik for helpful discussions; and the study participants whose help is greatly appreciated. P.B. was supported by the European Union{\textquoteright}s Horizon 2020 research and innovation programme under a Marie Sk{\l}odowska-Curie grant (agreement no. 846793), and by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (no. 27238). A.S. received funding from the European Union{\textquoteright}s Horizon 2020 research and from an innovation programme under a Marie Sk{\l}odowska-Curie grant (agreement no. 794986). The authors acknowledge support from the Austrian Science Fund (FWF) (grants P 30701 and KLI 718 to W.B., I 6037 to B.S., KLI 782 to T.S., and KLI 646 to G.H.). W.B. acknowledges the support of the following NIH grant: R01EB031787. D.K.D. acknowledges support from the following National Institutes of Health grants: BTRC P41 EB027061 and P30 NS076408 0 Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2023",

doi = "10.1038/s41551-023-01035-z",

language = "English (US)",

journal = "Nature Biomedical Engineering",

issn = "2157-846X",

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T1 - 1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain

AU - Bednarik, Petr

AU - Goranovic, Dario

AU - Svatkova, Alena

AU - Niess, Fabian

AU - Hingerl, Lukas

AU - Strasser, Bernhard

AU - Deelchand, Dinesh K.

AU - Spurny-Dworak, Benjamin

AU - Krssak, Martin

AU - Trattnig, Siegfried

AU - Hangel, Gilbert

AU - Scherer, Thomas

AU - Lanzenberger, Rupert

AU - Bogner, Wolfgang

N1 - Funding Information: We thank P. Bolan of the Center for Magnetic Resonance Research, University of Minnesota, and C. Rogers, University of Cambridge, for providing a tool to store and apply 7 T B-shims for the 7 T MR scanner; V. Mlynarik for helpful discussions; and the study participants whose help is greatly appreciated. P.B. was supported by the European Union’s Horizon 2020 research and innovation programme under a Marie Skłodowska-Curie grant (agreement no. 846793), and by a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (no. 27238). A.S. received funding from the European Union’s Horizon 2020 research and from an innovation programme under a Marie Skłodowska-Curie grant (agreement no. 794986). The authors acknowledge support from the Austrian Science Fund (FWF) (grants P 30701 and KLI 718 to W.B., I 6037 to B.S., KLI 782 to T.S., and KLI 646 to G.H.). W.B. acknowledges the support of the following NIH grant: R01EB031787. D.K.D. acknowledges support from the following National Institutes of Health grants: BTRC P41 EB027061 and P30 NS076408 0 Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2023

Y1 - 2023

N2 - Impaired glucose metabolism in the brain has been linked to several neurological disorders. Positron emission tomography and carbon-13 magnetic resonance spectroscopic imaging (MRSI) can be used to quantify the metabolism of glucose, but these methods involve exposure to radiation, cannot quantify downstream metabolism, or have poor spatial resolution. Deuterium MRSI (2H-MRSI) is a non-invasive and safe alternative for the quantification of the metabolism of 2H-labelled substrates such as glucose and their downstream metabolic products, yet it can only measure a limited number of deuterated compounds and requires specialized hardware. Here we show that proton MRSI (1H-MRSI) at 7 T has higher sensitivity, chemical specificity and spatiotemporal resolution than 2H-MRSI. We used 1H-MRSI in five volunteers to differentiate glutamate, glutamine, γ-aminobutyric acid and glucose deuterated at specific molecular positions, and to simultaneously map deuterated and non-deuterated metabolites. 1H-MRSI, which is amenable to clinically available magnetic-resonance hardware, may facilitate the study of glucose metabolism in the brain and its potential roles in neurological disorders.

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