13C editing of glutamate in human brain using J-refocused coherence transfer spectroscopy at 4.1 T

Jullie W. Pan, Graeme F. Mason, J. Thomas Vaughan, Wen Jang Chu, Yantian Zhang, Hoby P. Hetherington

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The method of single quantum 13C editing is analyzed and implemented with water suppressed J-refocused coherence transfer spectroscopy. Analysis of the 13C inversion pulse demonstrates that it is optimally placed into the second echo of the J-refocused sequence. We have used this method to acquire 13C-edited spectra of glutamate from phantoms and in vivo. The turnover of 13C4-labeled glutamate in human brain in vivo was observed in parasagittal gray matter using a volume head coil at 4.1 T with a time resolution of 5.3 min.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalMagnetic resonance in medicine
Volume37
Issue number3
DOIs
StatePublished - Mar 1997

Keywords

  • C
  • brain metabolism
  • coherence transfer spectroscopy
  • glutamate

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