SUMO: A ubiquitin-like protein modifier

Mary B. Kroetz

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


SUMO (Small Ubiquitin-related Modifier) is a small protein that covalently attaches to a lysine residue of another protein in a reversible fashion. SUMO attachment to its substrate proteins causes changes in the localization, activity, or binding partners of the substrate. SUMO has been shown to play a role in a multitude of processes; these include chromosome segregation, cell cycle progression, and DNA damage recovery. Defects in the SUMO pathway have been demonstrated to affect tumorigenesis and the inflammatory response as well as other human diseases.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalYale Journal of Biology and Medicine
Issue number4
StatePublished - Jul 2005
Externally publishedYes


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