Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage

Beth K Thielen; Erica Bye; Xiong Wang; Stacene Maroushek; Hannah Friedlander; Sarah Bistodeau; Jaime Christensen; Erik Reisdorf; Meghan H Shilts; Karen Martin; Kathryn Como-Sabetti; Anna K Strain; Patricia Ferrieri; Ruth Lynfield

doi:10.1093/infdis/jiaa075

Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage

Beth K Thielen, Erica Bye, Xiong Wang, Stacene Maroushek, Hannah Friedlander, Sarah Bistodeau, Jaime Christensen, Erik Reisdorf, Meghan H Shilts, Karen Martin, Kathryn Como-Sabetti, Anna K Strain, Patricia Ferrieri, Ruth Lynfield

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Abstract

BACKGROUND: Respiratory syncytial virus (RSV) typically causes winter outbreaks in temperate climates. During summer 2017, the Minnesota Department of Health (MDH) received a report of an increased cases of severe RSV-B infection.

METHODS: We compared characteristics of summer 2017 cases with those from the surrounding 4 summers (2014-2018). To understand the genetic relatedness among viruses, we performed high-throughput sequencing of RSV from patients with a spectrum of illness from multiple clinical sites in Minnesota and Wisconsin.

RESULTS: From May-Sept. 2017, 58 cases of RSV (43 RSV-B) were reported compared to 20-29 cases (3-7 RSV-B) during the same time frame in other years. The median age and frequency of co-morbidities was similar, but 55% (24/43) were admitted to the ICU in 2017 compared to 12% in preceding 3 years (OR: 4.84, p<0.01). Sequencing was performed on 137 specimens from March 2016-March 2018. Outbreak cases formed a unique clade sharing a single conserved non-synonymous change in the SH gene. We observed increased cases during the following winter season, during which time the new lineage was the predominant circulating strain.

CONCLUSIONS: We identified an outbreak of severe RSV-B disease associated with a new genetic lineage among urban Minnesota children during a time of expected low RSV circulation.

Original language	English (US)
Pages (from-to)	288-297
Number of pages	10
Journal	The Journal of infectious diseases
Volume	222
Issue number	2
Early online date	Feb 20 2020
DOIs	https://doi.org/10.1093/infdis/jiaa075
State	Published - Jun 29 2020

Bibliographical note

Funding Information:
Financial support. This work was supported by the Centers for Disease Control and Prevention (grant number CDC-RFA-CK17-170102CONT18 cooperative agreement to the Emerging Infections Program); and the National Institutes of Health (grant number T32 5T32AI055433-14 to B. K. T.).

Publisher Copyright:
© The Author(s) 2020.

Keywords

molecular epidemiology
respiratory infections
respiratory syncytial virus
viral next-generation sequencing
viral pathogenesis

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiaa075

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Thielen, B. K., Bye, E., Wang, X., Maroushek, S., Friedlander, H., Bistodeau, S., Christensen, J., Reisdorf, E., Shilts, M. H., Martin, K., Como-Sabetti, K., Strain, A. K., Ferrieri, P., & Lynfield, R. (2020). Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage. The Journal of infectious diseases, 222(2), 288-297. https://doi.org/10.1093/infdis/jiaa075

Thielen, BK, Bye, E, Wang, X, Maroushek, S, Friedlander, H, Bistodeau, S, Christensen, J, Reisdorf, E, Shilts, MH, Martin, K, Como-Sabetti, K, Strain, AK, Ferrieri, P & Lynfield, R 2020, 'Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage', The Journal of infectious diseases, vol. 222, no. 2, pp. 288-297. https://doi.org/10.1093/infdis/jiaa075

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title = "Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage",

abstract = "BACKGROUND: Respiratory syncytial virus (RSV) typically causes winter outbreaks in temperate climates. During summer 2017, the Minnesota Department of Health (MDH) received a report of an increased cases of severe RSV-B infection.METHODS: We compared characteristics of summer 2017 cases with those from the surrounding 4 summers (2014-2018). To understand the genetic relatedness among viruses, we performed high-throughput sequencing of RSV from patients with a spectrum of illness from multiple clinical sites in Minnesota and Wisconsin.RESULTS: From May-Sept. 2017, 58 cases of RSV (43 RSV-B) were reported compared to 20-29 cases (3-7 RSV-B) during the same time frame in other years. The median age and frequency of co-morbidities was similar, but 55% (24/43) were admitted to the ICU in 2017 compared to 12% in preceding 3 years (OR: 4.84, p<0.01). Sequencing was performed on 137 specimens from March 2016-March 2018. Outbreak cases formed a unique clade sharing a single conserved non-synonymous change in the SH gene. We observed increased cases during the following winter season, during which time the new lineage was the predominant circulating strain.CONCLUSIONS: We identified an outbreak of severe RSV-B disease associated with a new genetic lineage among urban Minnesota children during a time of expected low RSV circulation.",

keywords = "molecular epidemiology, respiratory infections, respiratory syncytial virus, viral next-generation sequencing, viral pathogenesis",

author = "Thielen, {Beth K} and Erica Bye and Xiong Wang and Stacene Maroushek and Hannah Friedlander and Sarah Bistodeau and Jaime Christensen and Erik Reisdorf and Shilts, {Meghan H} and Karen Martin and Kathryn Como-Sabetti and Strain, {Anna K} and Patricia Ferrieri and Ruth Lynfield",

note = "Funding Information: Financial support. This work was supported by the Centers for Disease Control and Prevention (grant number CDC-RFA-CK17-170102CONT18 cooperative agreement to the Emerging Infections Program); and the National Institutes of Health (grant number T32 5T32AI055433-14 to B. K. T.). Publisher Copyright: {\textcopyright} The Author(s) 2020.",

year = "2020",

month = jun,

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doi = "10.1093/infdis/jiaa075",

language = "English (US)",

volume = "222",

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T1 - Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage

AU - Thielen, Beth K

AU - Bye, Erica

AU - Wang, Xiong

AU - Maroushek, Stacene

AU - Friedlander, Hannah

AU - Bistodeau, Sarah

AU - Christensen, Jaime

AU - Reisdorf, Erik

AU - Shilts, Meghan H

AU - Martin, Karen

AU - Como-Sabetti, Kathryn

AU - Strain, Anna K

AU - Ferrieri, Patricia

AU - Lynfield, Ruth

N1 - Funding Information: Financial support. This work was supported by the Centers for Disease Control and Prevention (grant number CDC-RFA-CK17-170102CONT18 cooperative agreement to the Emerging Infections Program); and the National Institutes of Health (grant number T32 5T32AI055433-14 to B. K. T.). Publisher Copyright: © The Author(s) 2020.

PY - 2020/6/29

Y1 - 2020/6/29

N2 - BACKGROUND: Respiratory syncytial virus (RSV) typically causes winter outbreaks in temperate climates. During summer 2017, the Minnesota Department of Health (MDH) received a report of an increased cases of severe RSV-B infection.METHODS: We compared characteristics of summer 2017 cases with those from the surrounding 4 summers (2014-2018). To understand the genetic relatedness among viruses, we performed high-throughput sequencing of RSV from patients with a spectrum of illness from multiple clinical sites in Minnesota and Wisconsin.RESULTS: From May-Sept. 2017, 58 cases of RSV (43 RSV-B) were reported compared to 20-29 cases (3-7 RSV-B) during the same time frame in other years. The median age and frequency of co-morbidities was similar, but 55% (24/43) were admitted to the ICU in 2017 compared to 12% in preceding 3 years (OR: 4.84, p<0.01). Sequencing was performed on 137 specimens from March 2016-March 2018. Outbreak cases formed a unique clade sharing a single conserved non-synonymous change in the SH gene. We observed increased cases during the following winter season, during which time the new lineage was the predominant circulating strain.CONCLUSIONS: We identified an outbreak of severe RSV-B disease associated with a new genetic lineage among urban Minnesota children during a time of expected low RSV circulation.

AB - BACKGROUND: Respiratory syncytial virus (RSV) typically causes winter outbreaks in temperate climates. During summer 2017, the Minnesota Department of Health (MDH) received a report of an increased cases of severe RSV-B infection.METHODS: We compared characteristics of summer 2017 cases with those from the surrounding 4 summers (2014-2018). To understand the genetic relatedness among viruses, we performed high-throughput sequencing of RSV from patients with a spectrum of illness from multiple clinical sites in Minnesota and Wisconsin.RESULTS: From May-Sept. 2017, 58 cases of RSV (43 RSV-B) were reported compared to 20-29 cases (3-7 RSV-B) during the same time frame in other years. The median age and frequency of co-morbidities was similar, but 55% (24/43) were admitted to the ICU in 2017 compared to 12% in preceding 3 years (OR: 4.84, p<0.01). Sequencing was performed on 137 specimens from March 2016-March 2018. Outbreak cases formed a unique clade sharing a single conserved non-synonymous change in the SH gene. We observed increased cases during the following winter season, during which time the new lineage was the predominant circulating strain.CONCLUSIONS: We identified an outbreak of severe RSV-B disease associated with a new genetic lineage among urban Minnesota children during a time of expected low RSV circulation.

KW - molecular epidemiology

KW - respiratory infections

KW - respiratory syncytial virus

KW - viral next-generation sequencing

KW - viral pathogenesis

U2 - 10.1093/infdis/jiaa075

DO - 10.1093/infdis/jiaa075

M3 - Article

C2 - 32083677

VL - 222

SP - 288

EP - 297

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

Summer outbreak of severe RSV-B disease, Minnesota, 2017 associated with emergence of a genetically distinct viral lineage

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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