Sulcal thickness as a vulnerability indicator for schizophrenia

Vina M. Goghari, Kelly Rehm, Cameron S. Carter, Angus MacDonald

    Research output: Contribution to journalArticlepeer-review

    43 Scopus citations


    Background: People with schizophrenia may demonstrate cortical abnormalities, with gyri and sulci potentially being differentially affected. Aims: To measure frontal and temporal sulcal cortical thickness, surface area and volume in the non-psychotic relatives of patients with schizophrenia as a potential vulnerability indicator for the disorder. Method: An automated parcellation method was used to measure the superior frontal, inferior frontal, cingulate, superior temporal and inferior temporal sulci in the relatives of patients (n=19) and controls (n=22). Results: Compared with controls, relatives had reversed hemispheric asymmetry in their cingulate sulcal thickness and a bilateral reduction in their superior temporal sulcal thickness. Conclusions: Cingulate and superior temporal sulcal thickness abnormalities may reflect neural abnormalities associated with the genetic liability to schizophrenia. Cortical thinning in these regions suggests that liability genes affect the dendrites, synapses or myelination process during the neurodevelopment of the cortical mantle. Declaration of interest: None. Funding detailed in Acknowledgements.

    Original languageEnglish (US)
    Pages (from-to)229-233
    Number of pages5
    JournalBritish Journal of Psychiatry
    Issue number3
    StatePublished - Sep 2007


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