Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

Alexander Y. Kim; Joseph H. Yacoub; David H. Field; Byoung Uk Park; Bhaskar Kallakury; Kyle E. Korolowicz; Stephan Menne

doi:10.1002/ame2.12100

Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

Alexander Y. Kim
, Joseph H. Yacoub
, David H. Field
, Byoung Uk Park
, Bhaskar Kallakury
, Kyle E. Korolowicz
, Stephan Menne

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.

Original language	English (US)
Pages (from-to)	98-102
Number of pages	5
Journal	Animal Models and Experimental Medicine
Volume	3
Issue number	1
DOIs	https://doi.org/10.1002/ame2.12100
State	Published - Mar 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

angiography
animal model
hepatocellular carcinoma
woodchuck

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10.1002/ame2.12100

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title = "Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies",

abstract = "The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.",

keywords = "angiography, animal model, hepatocellular carcinoma, woodchuck",

author = "Kim, \{Alexander Y.\} and Yacoub, \{Joseph H.\} and Field, \{David H.\} and Park, \{Byoung Uk\} and Bhaskar Kallakury and Korolowicz, \{Kyle E.\} and Stephan Menne",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. Animal Models and Experimental Medicine published by John Wiley \& Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.",

year = "2020",

month = mar,

doi = "10.1002/ame2.12100",

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TY - JOUR

T1 - Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

AU - Kim, Alexander Y.

AU - Yacoub, Joseph H.

AU - Field, David H.

AU - Park, Byoung Uk

AU - Kallakury, Bhaskar

AU - Korolowicz, Kyle E.

AU - Menne, Stephan

PY - 2020/3

Y1 - 2020/3

N2 - The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.

AB - The most commonly used preclinical models of hepatocellular carcinoma (HCC) are limited for use in testing of intra-arterial therapies such as transarterial chemoembolization and radioembolization. Issues encountered with the more commonly used animal models include dissimilarity in their disease development compared with humans and the size of the vasculature which can make intra-arterial therapy testing difficult or impossible. Here we describe the suitability of the woodchuck HCC model for testing of intra-arterial therapies. We describe the techniques for pre-embolization imaging assessment using CT and MRI, technical tips on performing angiography and embolization, and pathological assessment of treated liver.

KW - angiography

KW - animal model

KW - hepatocellular carcinoma

KW - woodchuck

UR - https://www.scopus.com/pages/publications/85108561778

UR - https://www.scopus.com/pages/publications/85108561778#tab=citedBy

U2 - 10.1002/ame2.12100

DO - 10.1002/ame2.12100

M3 - Comment/debate

C2 - 32318666

AN - SCOPUS:85108561778

SN - 2096-5451

VL - 3

SP - 98

EP - 102

JO - Animal Models and Experimental Medicine

JF - Animal Models and Experimental Medicine

IS - 1

ER -

Suitability of the woodchuck HCC as a preclinical model for evaluation of intra-arterial therapies

Abstract

Bibliographical note

UN SDGs

Keywords

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