Suitability Criteria for Adult Related Donors: A Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues

Nina Worel, Andreas Buser, Hildegard T. Greinix, Hans Hägglund, Willis Navarro, Michael A. Pulsipher, Grazia Nicoloso de Faveri, Mats Bengtsson, Annelies Billen, German Espino, Mirjam Fechter, Valeria Giudice, Kristina Hölig, Heiwa Kanamori, Yoshihisa Kodera, Gerda Leitner, Tanja Netelenbos, Dietger Niederwieser, Suzanna M. van Walraven, Vanderson RochaTigran Torosian, Carmen Vergueiro, Daniel Weisdorf, Hiromasa Yabe, Jörg P. Halter

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The number of allogeneic hematopoietic stem cell (HSC) transplants performed globally each year continues to increase. Advances in HLA typing, better supportive care, and administration of reduced-intensity conditioning regimens allow treatment of older patients with older sibling donors. Pretransplant donor assessment and testing are very important processes affecting the quality and safety of donation. For unrelated HSC donors detailed recommendations for health assessment have been published, allowing donation only if they are unrestrictedly healthy. Eligibility criteria for related donors are less strict and vary significantly between centers. In situations where a family donor does not meet the suitability criteria for unrelated donors, involved physicians often struggle with the decision whether the matched relative is suitable for donation or not. On behalf of the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues, we intended to develop a consensus document with recommendations for donor workup and final clearance of family donors who would not be able to serve as unrelated donors because of their age or pre-existing diseases. This article covers different topics intending to support decision-making, with the goal of minimizing medical risk to the donor and protection of the recipient from transmissible diseases.

Original languageEnglish (US)
Pages (from-to)2052-2060
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number12
DOIs
StatePublished - Dec 2015

Bibliographical note

Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.

Keywords

  • Related stem cell donor
  • Suitability criteria

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