Suicidal ideation during interferon-α2b and ribavirin treatment of patients with chronic hepatitis C

Eric Dieperink; Samuel B. Ho; Lori Tetrick; Paul Thuras; Kulwinder Dua; Mark L. Willenbring

doi:10.1016/j.genhosppsych.2004.01.003

Suicidal ideation during interferon-α2b and ribavirin treatment of patients with chronic hepatitis C

Eric Dieperink
, Samuel B. Ho
, Lori Tetrick
, Paul Thuras
, Kulwinder Dua
, Mark L. Willenbring

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Psychiatric and substance use disorders affect most patients with chronic hepatitis C and are the most common reasons for exclusion from antiviral therapies. Suicidal ideation (SI) is often cited as a reason to exclude patients from interferon-based treatment or to terminate antiviral treatment that is in progress. This study examines SI in hepatitis C patients untreated and treated with interferon-α2b, a medication commonly associated with depression. Fifty-five subjects with chronic hepatitis C were followed for 24 weeks with three measures of depression, each containing one item assessing SI. A total of 15/55 (27%) subjects reported SI while not on interferon therapy. Of the 42 patients treated with interferon, 18 (43%) endorsed SI at some point during antiviral treatment. However, 17/18 (94%) finished at least a 6-month course of interferon therapy. No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment.

Original language	English (US)
Pages (from-to)	237-240
Number of pages	4
Journal	General Hospital Psychiatry
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.genhosppsych.2004.01.003
State	Published - May 2004

Bibliographical note

Funding Information:
This work was supported by the Minneapolis Hepatitis C Resource Center, the Research Service of the Department of Veterans Affairs and an unrestricted grant form Schering-Plough. The following people made substantial contributions to the study: Kristen Phillips, Gunnar Larson, Arnold Valerius, William Townsend.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Depression
Hepatitis C
Interferon
Psychiatric disorders
Suicidal ideation

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10.1016/j.genhosppsych.2004.01.003

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title = "Suicidal ideation during interferon-α2b and ribavirin treatment of patients with chronic hepatitis C",

abstract = "Psychiatric and substance use disorders affect most patients with chronic hepatitis C and are the most common reasons for exclusion from antiviral therapies. Suicidal ideation (SI) is often cited as a reason to exclude patients from interferon-based treatment or to terminate antiviral treatment that is in progress. This study examines SI in hepatitis C patients untreated and treated with interferon-α2b, a medication commonly associated with depression. Fifty-five subjects with chronic hepatitis C were followed for 24 weeks with three measures of depression, each containing one item assessing SI. A total of 15/55 (27\%) subjects reported SI while not on interferon therapy. Of the 42 patients treated with interferon, 18 (43\%) endorsed SI at some point during antiviral treatment. However, 17/18 (94\%) finished at least a 6-month course of interferon therapy. No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment.",

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note = "Funding Information: This work was supported by the Minneapolis Hepatitis C Resource Center, the Research Service of the Department of Veterans Affairs and an unrestricted grant form Schering-Plough. The following people made substantial contributions to the study: Kristen Phillips, Gunnar Larson, Arnold Valerius, William Townsend.",

year = "2004",

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doi = "10.1016/j.genhosppsych.2004.01.003",

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AU - Thuras, Paul

AU - Dua, Kulwinder

AU - Willenbring, Mark L.

N1 - Funding Information: This work was supported by the Minneapolis Hepatitis C Resource Center, the Research Service of the Department of Veterans Affairs and an unrestricted grant form Schering-Plough. The following people made substantial contributions to the study: Kristen Phillips, Gunnar Larson, Arnold Valerius, William Townsend.

PY - 2004/5

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N2 - Psychiatric and substance use disorders affect most patients with chronic hepatitis C and are the most common reasons for exclusion from antiviral therapies. Suicidal ideation (SI) is often cited as a reason to exclude patients from interferon-based treatment or to terminate antiviral treatment that is in progress. This study examines SI in hepatitis C patients untreated and treated with interferon-α2b, a medication commonly associated with depression. Fifty-five subjects with chronic hepatitis C were followed for 24 weeks with three measures of depression, each containing one item assessing SI. A total of 15/55 (27%) subjects reported SI while not on interferon therapy. Of the 42 patients treated with interferon, 18 (43%) endorsed SI at some point during antiviral treatment. However, 17/18 (94%) finished at least a 6-month course of interferon therapy. No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment.

AB - Psychiatric and substance use disorders affect most patients with chronic hepatitis C and are the most common reasons for exclusion from antiviral therapies. Suicidal ideation (SI) is often cited as a reason to exclude patients from interferon-based treatment or to terminate antiviral treatment that is in progress. This study examines SI in hepatitis C patients untreated and treated with interferon-α2b, a medication commonly associated with depression. Fifty-five subjects with chronic hepatitis C were followed for 24 weeks with three measures of depression, each containing one item assessing SI. A total of 15/55 (27%) subjects reported SI while not on interferon therapy. Of the 42 patients treated with interferon, 18 (43%) endorsed SI at some point during antiviral treatment. However, 17/18 (94%) finished at least a 6-month course of interferon therapy. No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment.

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KW - Hepatitis C

KW - Interferon

KW - Psychiatric disorders

KW - Suicidal ideation

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Suicidal ideation during interferon-α2b and ribavirin treatment of patients with chronic hepatitis C

Abstract

Bibliographical note

UN SDGs

Keywords

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