Sudden Onset Iron Overload Cardiomyopathy After Liver Transplantation

Alma Habib, Adnan Shaaban, Julie Thompson, Srinath Chinnakotla, Cindy M. Martin, Gregory M. Vercellotti

Research output: Contribution to journalArticlepeer-review


Iron overload cardiomyopathy has been described in patients who develop acute heart failure after liver transplantation but few reports of this are available. We present a case of a patient with end-stage liver disease who underwent a deceased donor liver transplantation and developed acute onset systolic heart failure with reduced left ventricular ejection fraction. A cardiac magnetic resonance image demonstrated late gadolinium enhancement with diffuse enhancement globally and T1 mapping with severely decreased pre-contrast T1 values suggesting iron overload cardiomyopathy. The patient was treated with iron chelating therapy as well as heart failure guideline-directed medical therapy with subsequent improvement in cardiac function on follow-up magnetic resonance images. Despite our patient’s diagnosis of iron overload cardiomyopathy, her iron studies showed normal serum iron and ferritin levels and no evidence of hepatic iron deposition in the transplanted liver.

Original languageEnglish (US)
JournalJournal of Investigative Medicine High Impact Case Reports
StatePublished - Jan 1 2023

Bibliographical note

Publisher Copyright:
© 2023 American Federation for Medical Research.


  • heart failure
  • hemochromatosis
  • iron overload
  • liver transplantation
  • nonischemic cardiomyopathy

PubMed: MeSH publication types

  • Case Reports
  • Journal Article


Dive into the research topics of 'Sudden Onset Iron Overload Cardiomyopathy After Liver Transplantation'. Together they form a unique fingerprint.

Cite this