Abstract
A 2-month-old girl presented for treatment with a diffuse rash, interstitial pneumonia, otorrhea, and lymphadenopathy. Skin biopsy confirmed Langerhans cell histocytosis by electron microscopy. After receiving multiple courses of chemotherapy, only marginal improvement was achieved, with progressive marrow and liver involvement. The decision was made to pursue a human leukocyte antigen-identical unrelated cord blood transplantation. Two years after transplant, the bone marrow was clear of Langerhans cell histocytosis and 100% donor engraftment. The poor prognosis of patients with an inadequate response to therapy and the presence of organ dysfunction (marrow and liver) substantiated the decision to pursue an unrelated cord blood transplantation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 629-632 |
| Number of pages | 4 |
| Journal | American Journal of Pediatric Hematology/Oncology |
| Volume | 23 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2001 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Bone marrow transplant
- Langerhans cell histiocytosis
- Umbilical cord blood transplant
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