Successful treatment of refractory langerhans cell histiocytosis with unrelated cord blood transplantation

Rajaram Nagarajan, Joseph Neglia, Norma Ramsay, K. Scott Baker

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

A 2-month-old girl presented for treatment with a diffuse rash, interstitial pneumonia, otorrhea, and lymphadenopathy. Skin biopsy confirmed Langerhans cell histocytosis by electron microscopy. After receiving multiple courses of chemotherapy, only marginal improvement was achieved, with progressive marrow and liver involvement. The decision was made to pursue a human leukocyte antigen-identical unrelated cord blood transplantation. Two years after transplant, the bone marrow was clear of Langerhans cell histocytosis and 100% donor engraftment. The poor prognosis of patients with an inadequate response to therapy and the presence of organ dysfunction (marrow and liver) substantiated the decision to pursue an unrelated cord blood transplantation.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume23
Issue number9
DOIs
StatePublished - 2001

Keywords

  • Bone marrow transplant
  • Langerhans cell histiocytosis
  • Umbilical cord blood transplant

Fingerprint

Dive into the research topics of 'Successful treatment of refractory langerhans cell histiocytosis with unrelated cord blood transplantation'. Together they form a unique fingerprint.

Cite this