Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac compromise

Cynthia L. Nicholson; Siobhan Flanagan; Michael Murati; Christina Boull; Erin McGough; Rebecca K Ameduri; Brenda Weigel; Sheilagh Maguiness

doi:10.1111/pde.14912

Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac compromise

Cynthia L. Nicholson, Siobhan Flanagan, Michael Murati, Christina Boull, Erin McGough, Rebecca K Ameduri, Brenda Weigel, Sheilagh Maguiness

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16-year-old woman with CM-AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.

Original language	English (US)
Pages (from-to)	316-319
Number of pages	4
Journal	Pediatric Dermatology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1111/pde.14912
State	Published - Mar 1 2022

Bibliographical note

Funding Information:
The authors thank Timothy Moss, MD PhD and Denise Adams, MD for their aid in the management decisions in this case.

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

Keywords

MEK inhibitor
skin signs of systemic disease
therapy-systemic
trametinib
vascular malformation

PubMed: MeSH publication types

Case Reports
Journal Article

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10.1111/pde.14912

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Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac compromise. / Nicholson, Cynthia L.; Flanagan, Siobhan ; Murati, Michael et al.
In: Pediatric Dermatology, Vol. 39, No. 2, 01.03.2022, p. 316-319.

Research output: Contribution to journal › Article › peer-review

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abstract = "Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16-year-old woman with CM-AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.",

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note = "Funding Information: The authors thank Timothy Moss, MD PhD and Denise Adams, MD for their aid in the management decisions in this case. Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",

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AU - Murati, Michael

AU - Boull, Christina

AU - McGough, Erin

AU - Ameduri, Rebecca K

AU - Weigel, Brenda

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AB - Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16-year-old woman with CM-AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.

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Successful management of an arteriovenous malformation with trametinib in a patient with capillary-malformation arteriovenous malformation syndrome and cardiac compromise

Abstract

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