Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

A. A. Ashrani; Mark T Reding; A. Shet; J. Osip; A. Humar; John R Lake; Nigel S. Key

doi:10.1111/j.1365-2516.2004.01030.x

Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

A. A. Ashrani, Mark T Reding, A. Shet, J. Osip, A. Humar, John R Lake, Nigel S. Key

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Abstract

We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.

Original language	English (US)
Pages (from-to)	735-737
Number of pages	3
Journal	Haemophilia
Volume	10
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2516.2004.01030.x
State	Published - Nov 2004

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abstract = "We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.",

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AU - Ashrani, A. A.

AU - Reding, Mark T

AU - Shet, A.

AU - Osip, J.

AU - Humar, A.

AU - Lake, John R

AU - Key, Nigel S.

PY - 2004/11

Y1 - 2004/11

N2 - We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.

AB - We present the case of a 61-year-old man with severe haemophilia A and a high-titre factor VIII inhibitor who underwent successful orthotopic liver transplantation (OLT) for hepatocellular carcinoma. Postoperatively, a modest early anamnestic response to FVIII was followed by immunological tolerance to FVIII. This case illustrates the technical feasibility of OLT in some patients with high-titre inhibitors to FVIII, and suggests that immune tolerance may be induced by endogenously produced FVIII from the transplanted organ.

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Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

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