Successful kidney transplant in a patient with IgG anti HLA Class-I auto-antibodies: A case report

Naji Alhamid, Hani Alterky, Amanda Almouslem, Heba Al-Rayess, Mohammad Imad Othman

Research output: Contribution to journalArticle

Abstract

Donor specific antibodies (DSA) play a significant role in graft rejection. Many laboratory methods, varied in sensitivity and specificity, are used to detect them. We report a case of a 38-year-old man presented with end stage renal disease considered for kidney transplantation. He had no history of blood transfusions nor transplantation procedures. Dilemma rose when he got multiple positive crossmatches with matching donors and a positive autologous crossmatch due to IgG anti HLA auto-antibodies, which are at the same time against matched donors. Since positive crossmatch is a contraindication for transplant, we couldn't perform transplant from any matched donor. Therefore, we considered a total mismatched donor then transplantation was performed. Observation after surgery showed normalization of creatinine, blood pressure and a good function of the planted allograft for two years of follow up.

Original languageEnglish (US)
Pages (from-to)597-601
Number of pages5
JournalHuman Immunology
Volume75
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • IgG anti HLA I autoantibodies
  • Kidney transplant

Fingerprint Dive into the research topics of 'Successful kidney transplant in a patient with IgG anti HLA Class-I auto-antibodies: A case report'. Together they form a unique fingerprint.

  • Cite this