Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report

Kristy Pilbeam, Ben Eidenschink, Megan Sulciner, Mark Luquette, Joseph P Neglia, Srinath Chinnakotla

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Abstract

Hepatic angiosarcoma is an extremely rare diagnosis in children, with fewer than 50 pediatric cases reported in the literature worldwide. This aggressive vascular sarcoma carries a very dismal prognosis and is known to be resistant to radiation, chemotherapy, and other vascular-targeted agents. Complete surgical resection is felt to provide the best chance for long-term survival. In patients with tumors not amenable to resection, a liver transplant can be considered. However, very few such transplants have been reported, given that they remain controversial due to high cancer recurrence and mortality post-transplant. Herein, we report the unique case of a 2-year-old child with localized hepatic angiosarcoma not amendable to resection who successfully underwent a liver transplant and received chemotherapy with six cycles of doxorubicin, docetaxel, and ifosfamide.

Original languageEnglish (US)
Article numbere13410
JournalPediatric transplantation
Volume23
Issue number4
DOIs
StatePublished - Jun 2019

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Keywords

  • angiosarcoma
  • hepatic angiosarcoma
  • liver transplantation

PubMed: MeSH publication types

  • Case Reports

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