Success of Checkpoint Blockade Paves the Way for Novel Immune Therapy in Malignant Pleural Mesothelioma

Lizbeth Rondon, Roberto Fu, Manish R. Patel

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Malignant pleural mesothelioma (MPM) is a malignancy associated with asbestos exposure and is typically categorized as an orphan disease. Recent developments in immunotherapy with anti-PD-1 and anti-CTLA-4 antibodies, specifically with agents nivolumab and ipilimumab, have demonstrated an improvement in overall survival over the previous standard chemotherapy leading to their FDA-approval as first-line therapy for unresectable disease. For quite some time, it has been known that these proteins are not the only ones that function as immune checkpoints in human biology, and the hypothesis that MPM is an immunogenic disease has led to an expanding number of studies investigating alternative checkpoint inhibitors and novel immunotherapy for this malignancy. Early trials are also supporting the notion that therapies that target biological molecules on T cells, cancer cells, or that trigger the antitumor activity of other immune cells may represent the future of MPM treatment. Moreover, mesothelin-targeted therapies are thriving in the field, with forthcoming results from multiple trials signaling an improvement in overall survival when combined with other immunotherapy agents. The following manuscript will review the current state of immune therapy for MPM, explore the knowledge gaps in the field, and discuss ongoing novel immunotherapeutic research in early clinical trials.

Original languageEnglish (US)
Article number2940
Issue number11
StatePublished - Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.


  • B7-H3
  • CAR-T cells
  • CTLA-4
  • NK cells
  • PD-1
  • PD-L1
  • immune checkpoint inhibitors
  • malignant pleural mesothelioma
  • mesothelin therapy

PubMed: MeSH publication types

  • Journal Article
  • Review


Dive into the research topics of 'Success of Checkpoint Blockade Paves the Way for Novel Immune Therapy in Malignant Pleural Mesothelioma'. Together they form a unique fingerprint.

Cite this