Abstract
Previous research has indicated increased functional connectivity between subthalamic nucleus (STN) and sensorimotor cortex in off-medication Parkinson's disease (PD) compared with control subjects. It is not clear if the increase in functional connectivity between STN and sensorimotor cortex occurs in de novo PD, which is before patients begin dopamine therapy. Resting-state functional magnetic resonance imaging was carried out in 20 de novo (drug naïve) patients with PD (Hoehn and Yahr stage: I-II), 19 patients with moderate PD (Hoehn and Yahr stage: II-III), and 19 healthy controls. The functional connectivity analysis in de novo and moderate PD patients focused on the connectivity of the more affected STN and the sensorimotor cortex. Using resting-state functional connectivity analysis, we provide new evidence that people with de novo PD and off-medicated moderate PD have increased functional connectivity between the more affected STN and different regions within the sensorimotor cortex. The overlapping sensorimotor cortex found in both de novo and moderate PD had functional connectivity values that correlated positively with the Unified Parkinson's Disease Rating Scale part III. This key finding suggests that changes in functional connectivity between STN and sensorimotor cortex occur early in the disease following diagnosis and before dopamine therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 462-469 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 36 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2015 |
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Keywords
- Connectivity
- Drug naive
- Parkinson's disease
- Subthalamic nucleus
Cite this
Subthalamic nucleus-sensorimotor cortex functional connectivity in de novo and moderate Parkinson's disease. / Kurani, Ajay S.; Seidler, Rachael D.; Burciu, Roxana G.; Comella, Cynthia L.; Corcos, Daniel M.; Okun, Michael S.; MacKinnon, Colum D.; Vaillancourt, David E.
In: Neurobiology of Aging, Vol. 36, No. 1, 01.01.2015, p. 462-469.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subthalamic nucleus-sensorimotor cortex functional connectivity in de novo and moderate Parkinson's disease
AU - Kurani, Ajay S.
AU - Seidler, Rachael D.
AU - Burciu, Roxana G.
AU - Comella, Cynthia L.
AU - Corcos, Daniel M.
AU - Okun, Michael S.
AU - MacKinnon, Colum D.
AU - Vaillancourt, David E.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Previous research has indicated increased functional connectivity between subthalamic nucleus (STN) and sensorimotor cortex in off-medication Parkinson's disease (PD) compared with control subjects. It is not clear if the increase in functional connectivity between STN and sensorimotor cortex occurs in de novo PD, which is before patients begin dopamine therapy. Resting-state functional magnetic resonance imaging was carried out in 20 de novo (drug naïve) patients with PD (Hoehn and Yahr stage: I-II), 19 patients with moderate PD (Hoehn and Yahr stage: II-III), and 19 healthy controls. The functional connectivity analysis in de novo and moderate PD patients focused on the connectivity of the more affected STN and the sensorimotor cortex. Using resting-state functional connectivity analysis, we provide new evidence that people with de novo PD and off-medicated moderate PD have increased functional connectivity between the more affected STN and different regions within the sensorimotor cortex. The overlapping sensorimotor cortex found in both de novo and moderate PD had functional connectivity values that correlated positively with the Unified Parkinson's Disease Rating Scale part III. This key finding suggests that changes in functional connectivity between STN and sensorimotor cortex occur early in the disease following diagnosis and before dopamine therapy.
AB - Previous research has indicated increased functional connectivity between subthalamic nucleus (STN) and sensorimotor cortex in off-medication Parkinson's disease (PD) compared with control subjects. It is not clear if the increase in functional connectivity between STN and sensorimotor cortex occurs in de novo PD, which is before patients begin dopamine therapy. Resting-state functional magnetic resonance imaging was carried out in 20 de novo (drug naïve) patients with PD (Hoehn and Yahr stage: I-II), 19 patients with moderate PD (Hoehn and Yahr stage: II-III), and 19 healthy controls. The functional connectivity analysis in de novo and moderate PD patients focused on the connectivity of the more affected STN and the sensorimotor cortex. Using resting-state functional connectivity analysis, we provide new evidence that people with de novo PD and off-medicated moderate PD have increased functional connectivity between the more affected STN and different regions within the sensorimotor cortex. The overlapping sensorimotor cortex found in both de novo and moderate PD had functional connectivity values that correlated positively with the Unified Parkinson's Disease Rating Scale part III. This key finding suggests that changes in functional connectivity between STN and sensorimotor cortex occur early in the disease following diagnosis and before dopamine therapy.
KW - Connectivity
KW - Drug naive
KW - Parkinson's disease
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=84920607102&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920607102&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2014.07.004
DO - 10.1016/j.neurobiolaging.2014.07.004
M3 - Article
C2 - 25095723
AN - SCOPUS:84920607102
VL - 36
SP - 462
EP - 469
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 1
ER -