Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe; Nicholas J. Race; John F. Bower; Cedric K.A. Callens

doi:10.1021/ol101681r

Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe
, Nicholas J. Race
, John F. Bower
, Cedric K.A. Callens

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

Original language	English (US)
Pages (from-to)	4094-4097
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	18
DOIs	https://doi.org/10.1021/ol101681r
State	Published - Sep 17 2010
Externally published	Yes

Publisher link

10.1021/ol101681r

Find It

Find It at U of M Libraries

Cite this

@article{d27aa337f4e7454caed13b74d050f01f,

title = "Substituted pyrroles via olefin cross-metathesis",

abstract = "Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.",

author = "Donohoe, \{Timothy J.\} and Race, \{Nicholas J.\} and Bower, \{John F.\} and Callens, \{Cedric K.A.\}",

year = "2010",

month = sep,

day = "17",

doi = "10.1021/ol101681r",

language = "English (US)",

volume = "12",

pages = "4094--4097",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Substituted pyrroles via olefin cross-metathesis

AU - Donohoe, Timothy J.

AU - Race, Nicholas J.

AU - Bower, John F.

AU - Callens, Cedric K.A.

PY - 2010/9/17

Y1 - 2010/9/17

N2 - Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

AB - Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

UR - https://www.scopus.com/pages/publications/77956604319

UR - https://www.scopus.com/pages/publications/77956604319#tab=citedBy

U2 - 10.1021/ol101681r

DO - 10.1021/ol101681r

M3 - Article

C2 - 20712303

AN - SCOPUS:77956604319

SN - 1523-7060

VL - 12

SP - 4094

EP - 4097

JO - Organic Letters

JF - Organic Letters

IS - 18

ER -

Substituted pyrroles via olefin cross-metathesis

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this