Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe, Nicholas J. Race, John F. Bower, Cedric K.A. Callens

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

Original languageEnglish (US)
Pages (from-to)4094-4097
Number of pages4
JournalOrganic Letters
Volume12
Issue number18
DOIs
StatePublished - Sep 17 2010
Externally publishedYes

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