Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe; Nicholas J. Race; John F. Bower; Cedric K.A. Callens

doi:10.1021/ol101681r

Substituted pyrroles via olefin cross-metathesis

Timothy J. Donohoe, Nicholas J. Race, John F. Bower, Cedric K.A. Callens

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

Original language	English (US)
Pages (from-to)	4094-4097
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	18
DOIs	https://doi.org/10.1021/ol101681r
State	Published - Sep 17 2010
Externally published	Yes

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10.1021/ol101681r

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title = "Substituted pyrroles via olefin cross-metathesis",

abstract = "Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.",

author = "Donohoe, {Timothy J.} and Race, {Nicholas J.} and Bower, {John F.} and Callens, {Cedric K.A.}",

year = "2010",

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doi = "10.1021/ol101681r",

language = "English (US)",

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journal = "Organic Letters",

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T1 - Substituted pyrroles via olefin cross-metathesis

AU - Donohoe, Timothy J.

AU - Race, Nicholas J.

AU - Bower, John F.

AU - Callens, Cedric K.A.

PY - 2010/9/17

Y1 - 2010/9/17

N2 - Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

AB - Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-γ-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

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JF - Organic Letters

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ER -

Substituted pyrroles via olefin cross-metathesis

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