TY - JOUR
T1 - Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude
AU - Iacono, William G.
AU - Malone, Stephen M.
AU - McGue, Matt
PY - 2003/5/1
Y1 - 2003/5/1
N2 - We hypothesize the existence of an inherited predisposition for a spectrum of behaviors and traits characterized by behavioral disinhibition. This externalizing spectrum includes childhood disruptive disorders, antisocial behavior, substance use disorders, personality traits related to behavioral undercontrol, and the precocious expression of problem behavior. We further hypothesize that a genetically influenced central nervous system diathesis underlies this spectrum and is reflected in reduced P300 amplitude in a visual oddball event-related potential task. A review of evidence bearing on the model is derived from findings from the Minnesota Twin Family Study, a population-based, longitudinal investigation of twin youth. These findings indicate that the collection of attributes related to behavioral disinhibition is familial, heritable, and interrelated. Evidence supporting P3 amplitude reduction (P3-AR) as an index of genetic vulnerability for this externalizing spectrum includes its association with (a) familial risk for substance use and antisocial personality disorders, (b) diagnoses of childhood disruptive disorders and substance use disorders, (c) early onset of undersocialized behavior, and (d) quantitative phenotypes related to externalizing problems. In addition, the development of substance use disorders over a 3-year period is associated with P3-AR measured prior to their expression. These findings suggest that P3-AR indexes one aspect of the genetic diathesis for a spectrum of externalizing problem behavior.
AB - We hypothesize the existence of an inherited predisposition for a spectrum of behaviors and traits characterized by behavioral disinhibition. This externalizing spectrum includes childhood disruptive disorders, antisocial behavior, substance use disorders, personality traits related to behavioral undercontrol, and the precocious expression of problem behavior. We further hypothesize that a genetically influenced central nervous system diathesis underlies this spectrum and is reflected in reduced P300 amplitude in a visual oddball event-related potential task. A review of evidence bearing on the model is derived from findings from the Minnesota Twin Family Study, a population-based, longitudinal investigation of twin youth. These findings indicate that the collection of attributes related to behavioral disinhibition is familial, heritable, and interrelated. Evidence supporting P3 amplitude reduction (P3-AR) as an index of genetic vulnerability for this externalizing spectrum includes its association with (a) familial risk for substance use and antisocial personality disorders, (b) diagnoses of childhood disruptive disorders and substance use disorders, (c) early onset of undersocialized behavior, and (d) quantitative phenotypes related to externalizing problems. In addition, the development of substance use disorders over a 3-year period is associated with P3-AR measured prior to their expression. These findings suggest that P3-AR indexes one aspect of the genetic diathesis for a spectrum of externalizing problem behavior.
KW - Alcoholism
KW - Antisocial Personality
KW - Behavioral disinhibition
KW - Childhood disruptive disorders
KW - Endophenotype
KW - Event-related potential
KW - Nicotine dependence
KW - P300
KW - Personality
KW - Substance use disorders
UR - http://www.scopus.com/inward/record.url?scp=0038184090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038184090&partnerID=8YFLogxK
U2 - 10.1016/S0167-8760(03)00052-7
DO - 10.1016/S0167-8760(03)00052-7
M3 - Article
C2 - 12763572
AN - SCOPUS:0038184090
VL - 48
SP - 147
EP - 178
JO - International Journal of Psychophysiology
JF - International Journal of Psychophysiology
SN - 0167-8760
IS - 2
ER -