Substance P receptor mediated maintenance of chronic inflammation in EAE

Emily K. Reinke, Matthew J. Johnson, Changying Ling, Jozsef Karman, Jang Eun Lee, Joel V. Weinstock, Matyas Sandor, Zsuzsa Fabry

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Substance P (SP) is a modulatory, pro-inflammatory neuropeptide. We investigated the role of the SP receptor, neurokinin-1 (NK-1), in EAE. Our data show that in the chronic phase, mice lacking NK-1 have improved mobility and decreased numbers of LFA-1 high CD4+ T cells and MOG-specific, IFN-γ producing CD4+ T cells. SR140333, an NK-1 antagonist, administered alone during the chronic phase of EAE was not sufficient to ameliorate symptoms. These results indicate that SP, through NK-1, contributes to maintenance of CNS inflammation, and combining NK-1 antagonists with conventional anti-inflammatory treatments may enhance the success of treatments for diseases like multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalJournal of Neuroimmunology
Volume180
Issue number1-2
DOIs
StatePublished - Nov 1 2006
Externally publishedYes

Keywords

  • EAE
  • MS
  • Neurokinin
  • Neuropeptide
  • SR140333
  • Substance P

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