Abstract
Substance P binding sites in the nucleus tractus solitarius were visualized with receptor autoradiography using Bolton-Hunter [125I]substance P. Substance P binding sites were found to have distinct patterns within the cat nucleus tractus solitarius. The majority of substance P binding sites were present in the medial, intermediate and the peripheral rim of the parvocellular subdivisions. Lower amounts of substance P binding sites were present in the commissural, ventrolateral, interstitial and dorsolateral subdivisions. No substance P binding sites were present in the central region of the parvocellular subdivision or the solitary tract. The localization of substance P binding sites in the nucleus tractus solitarius is very similar to the patterns of substance P immunoreactive fibers previously described for this region. Results of this study add further support for a functional role of substance P in synaptic circuits of the nucleus tractus solitarius.
Original language | English (US) |
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Pages (from-to) | 1301-1306 |
Number of pages | 6 |
Journal | Peptides |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - 1988 |
Externally published | Yes |
Keywords
- Autonomic nervous system
- Cardiovascular
- Nucleus tractus solitarius
- Receptors
- Respiratory
- Substance P