Substance P binding sites in the nucleus tractus solitarius of the cat

Bruce E. Maley, Cathrine A. Sasek, Virginia S. Seybold

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Substance P binding sites in the nucleus tractus solitarius were visualized with receptor autoradiography using Bolton-Hunter [125I]substance P. Substance P binding sites were found to have distinct patterns within the cat nucleus tractus solitarius. The majority of substance P binding sites were present in the medial, intermediate and the peripheral rim of the parvocellular subdivisions. Lower amounts of substance P binding sites were present in the commissural, ventrolateral, interstitial and dorsolateral subdivisions. No substance P binding sites were present in the central region of the parvocellular subdivision or the solitary tract. The localization of substance P binding sites in the nucleus tractus solitarius is very similar to the patterns of substance P immunoreactive fibers previously described for this region. Results of this study add further support for a functional role of substance P in synaptic circuits of the nucleus tractus solitarius.

Original languageEnglish (US)
Pages (from-to)1301-1306
Number of pages6
JournalPeptides
Volume9
Issue number6
DOIs
StatePublished - 1988

Keywords

  • Autonomic nervous system
  • Cardiovascular
  • Nucleus tractus solitarius
  • Receptors
  • Respiratory
  • Substance P

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