Subjective response to nicotine by menstrual phase

Alicia M. Allen, Scott Lunos, Stephen J. Heishman, Mustafa al'Absi, Dorothy Hatsukami, Sharon S. Allen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Introduction: The luteal menstrual phase might be a favorable time for smoking cessation when non-nicotine interventions (e.g. counseling, bupropion) are used, whereas the follicular menstrual phase appears favorable when nicotine interventions are used. Thus, there may be an interaction between menstrual phase and response to nicotine. We sought to examine the role of menstrual phase on response to nicotine during acute smoking abstinence. Methods: In this controlled cross-over trial, women completed two identical experimental sessions (follicular [F] vs. luteal [L] phase) after four days of biochemically-verified smoking abstinence. During the sessions, nicotine nasal spray was administered, and participants provided a series of subjective assessments. Results: Participants (n = 140) were 29.7 ± 6.6 years old and smoked 12.6 ± 5.8 cigarettes per day. Compared to the F phase, the L phase was associated with a greater increase in stimulation (7.2 ± 2.2 vs. 14.4 ± 2.3, p = 0.01, respectively) and greater decrease in urge to smoke (- 13.6 ± 2.3 vs - 21.1 ± 2.5, p = 0.02, respectively) after the first dose of nicotine. No other significant differences were observed. Conclusions: Out of 13 total measures examined at two different time points, we observed only two significant menstrual phase differences in the subjective response to nicotine. Therefore, these data do not provide strong evidence for a menstrual phase difference in the subjective response to nicotine. Additional research is needed to confirm this relationship and explore how non-nicotine smoking reinforcements (such as sensory sensations) may vary by menstrual phase.

Original languageEnglish (US)
Pages (from-to)50-53
Number of pages4
JournalAddictive Behaviors
Issue number1
StatePublished - 2015

Bibliographical note

Funding Information:
This project was funded by National Institute on Drug Abuse (NIDA) Grant R01-DA08075 and supported by the Intramural Research Program of the NIH, National Institute on Drug Abuse . ). A. Allen was supported by the University of Minnesota’s Masonic Cancer Center and the Building Interdisciplinary Research Careers in Women’s Health Grant (# K12HD055887 ; A. Allen) from the Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD), the Office of Research on Women’s Health , and the National Institute on Aging, NIH , administered by the University of Minnesota Deborah E. Powell Center for Women’s Health. Additional support was provided by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 .The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2014 Elsevier Ltd.


  • Addiction
  • Hormones
  • Menstrual cycle
  • Nicotine
  • Smoking


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