TY - JOUR
T1 - Subepithelial space in otitis media
AU - Paparella, Michael M.
AU - Sipilä, Pekka
AU - Juhn, S. K.
AU - Jung, Timothy T.K.
PY - 1985/4
Y1 - 1985/4
N2 - The role of the subepithelial space (SES) has not received sufficient attention in assessing pathogenesis, pathology, and, therefore, clinical diagnosis and treatment of the various forms of otitis media (OMI. Temporal bones from patients with OM were classified as cases of acute purulent (POM), serous (SOM), mucoid or secretory (MOM), or chronic otitis media (COM). Controlled morphometric studies were made of cellular components of the SES, along with studies of the epithelium and middle car space. Corollary studies of biochemistry, cellular components, and prostaglandins (PGs) were done on fluid from the human middle ear. Middle ear effusions (MEE) from animal models of SOM, MOM, and POM were analyzed biochemically. Findings are surprising in that the SES was more actively involved in all forms of OM than had been thought, especially in MOM and COM. Implications are discussed.
AB - The role of the subepithelial space (SES) has not received sufficient attention in assessing pathogenesis, pathology, and, therefore, clinical diagnosis and treatment of the various forms of otitis media (OMI. Temporal bones from patients with OM were classified as cases of acute purulent (POM), serous (SOM), mucoid or secretory (MOM), or chronic otitis media (COM). Controlled morphometric studies were made of cellular components of the SES, along with studies of the epithelium and middle car space. Corollary studies of biochemistry, cellular components, and prostaglandins (PGs) were done on fluid from the human middle ear. Middle ear effusions (MEE) from animal models of SOM, MOM, and POM were analyzed biochemically. Findings are surprising in that the SES was more actively involved in all forms of OM than had been thought, especially in MOM and COM. Implications are discussed.
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M3 - Article
C2 - 2984491
AN - SCOPUS:0021813941
SN - 0023-852X
VL - 95
SP - 414
EP - 420
JO - Laryngoscope
JF - Laryngoscope
IS - 4
ER -