TY - JOUR
T1 - Subcutaneous cryptococcosis due to Cryptococcus diffluens in a patient with sporotrichoid lesions case report, features of the case isolate and in vitro antifungal susceptibilities
AU - Kantarcioǧlu, A. Serda
AU - Boekhout, Teun
AU - De Hoog, G. Sybren
AU - Theelen, Bart
AU - Yücel, Ayhan
AU - Ekmekci, Tuba
AU - Fries, Bettina
AU - Ikeda, Reiko
AU - Koslu, Adem
AU - Altas, Kemal
PY - 2007/3
Y1 - 2007/3
N2 - Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy, young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification.
AB - Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy, young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification.
KW - Antifungals
KW - Cryptococcal antigens
KW - Cryptococcus diffluens
KW - Phenotypical switching
KW - Primary subcutaneous cryptococcosis
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U2 - 10.1080/13693780601045166
DO - 10.1080/13693780601045166
M3 - Article
C2 - 17365654
AN - SCOPUS:33847754993
SN - 1369-3786
VL - 45
SP - 173
EP - 181
JO - Medical mycology
JF - Medical mycology
IS - 2
ER -