Subcutaneous cryptococcosis due to Cryptococcus diffluens in a patient with sporotrichoid lesions case report, features of the case isolate and in vitro antifungal susceptibilities

A. Serda Kantarcioǧlu, Teun Boekhout, G. Sybren De Hoog, Bart Theelen, Ayhan Yücel, Tuba Ekmekci, Bettina Fries, Reiko Ikeda, Adem Koslu, Kemal Altas

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Environmental fungi, in particular primary pathogens and Cryptococcus spp. can be responsible for skin lesions mimicking sporotrichosis. In this paper, we report a case of subcutaneous cryptococcosis in an apparently healthy, young male patient due to a non-C. neoformans Cryptococcus species, C. diffluens. The isolate showed in vitro phenotypic switching that may affect virulence and host inflammatory and immune responses, and in vitro resistance to amphotericin B and 5-flucytosin. This species shares several phenotypic traits with C. neoformans, and, therefore, decisive diagnosis should be based on biopsy and culturing results followed by molecular identification.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalMedical mycology
Volume45
Issue number2
DOIs
StatePublished - Mar 2007
Externally publishedYes

Keywords

  • Antifungals
  • Cryptococcal antigens
  • Cryptococcus diffluens
  • Phenotypical switching
  • Primary subcutaneous cryptococcosis

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