TY - JOUR
T1 - Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis
AU - Karachunski, Peter I.
AU - Ostlie, Norma S.
AU - Okita, David K.
AU - Garman, Richard
AU - Conti-Fine, Bianca M.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis (EMG). The s.c. administration to C57B1/6 mice of synthetic AChR CD4+ epitopes, before and during AChR immunization, reduced the epitope-specific CD4+ responses and the anti-AChR Ab synthesis, and prevented EMG. The s.c. administration of solubilized AChR had effects similar to those of peptide treatment. Sham-tolerized mice had only Th1 anti- AChR cells, whereas peptide-treated mice had also Th2 cells, and Th2-induced anti-peptide Ab. Established EMG was not affected by s.c. peptide treatment, whereas it worsened after s.c. administration of solubilized AChR.
AB - Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis (EMG). The s.c. administration to C57B1/6 mice of synthetic AChR CD4+ epitopes, before and during AChR immunization, reduced the epitope-specific CD4+ responses and the anti-AChR Ab synthesis, and prevented EMG. The s.c. administration of solubilized AChR had effects similar to those of peptide treatment. Sham-tolerized mice had only Th1 anti- AChR cells, whereas peptide-treated mice had also Th2 cells, and Th2-induced anti-peptide Ab. Established EMG was not affected by s.c. peptide treatment, whereas it worsened after s.c. administration of solubilized AChR.
KW - Acetylcholine receptor
KW - Autoimmunity
KW - Experimental myasthenia gravis
KW - Subcutaneous tolerance
KW - Th2 cells
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U2 - 10.1016/S0165-5728(98)00208-2
DO - 10.1016/S0165-5728(98)00208-2
M3 - Article
C2 - 10378874
AN - SCOPUS:0032917213
SN - 0165-5728
VL - 93
SP - 108
EP - 121
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -