Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy

Jessica A. Boyette-Davis, Cathy Eng, Xin S. Wang, Charles S. Cleeland, Gwen Wendelschafer-Crabb, William R Kennedy, Donald A Simone, Haijun Zhang, Patrick M. Dougherty

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: Of the numerous complications associated with cancer and cancer treatment, peripheral neuropathy is a deleterious and persistent patient complaint commonly attributed to chemotherapy. The present study investigated the occurrence of subclinical peripheral neuropathy in patients with colorectal cancer before the initiation of chemotherapy. Experimental Design: Fifty-two patients underwent extensive quantitative sensory testing (QST) before receiving chemotherapy. Changes in multiple functions of primary afferent fibers were assessed and compared with a group of healthy control subjects. Skin temperature, sensorimotor function, sharpness detection, and thermal detection were measured, as was touch detection, using both conventional (von Frey monofilaments) and novel (Bumps detection test) methodology. Results: Patients had subclinical deficits, especially in sensorimotor function, detection of thermal stimuli, and touch detection that were present before the initiation of chemotherapy. The measured impairment in touch sensation was especially pronounced when using the Bumps detection test. Conclusions: The patients with colorectal cancer in this study exhibited deficits in sensory function before undergoing chemotherapy treatment, implicating the disease itself as a contributing factor in chemotherapy-induced peripheral neuropathy. The widespread nature of the observed deficits further indicated that cancer is affecting multiple primary afferent subtypes. Specific to the finding of impaired touch sensation, results from this study highlight the use of newly used methodology, the Bumps detection test, as a sensitive and useful tool in the early detection of peripheral neuropathy.

Original languageEnglish (US)
Pages (from-to)3180-3187
Number of pages8
JournalClinical Cancer Research
Volume18
Issue number11
DOIs
StatePublished - Jun 1 2012

Fingerprint

Peripheral Nervous System Diseases
Colorectal Neoplasms
Touch
Drug Therapy
Hot Temperature
Neoplasms
Skin Temperature
Hypesthesia
Healthy Volunteers
Research Design
Control Groups
Therapeutics

Cite this

Boyette-Davis, J. A., Eng, C., Wang, X. S., Cleeland, C. S., Wendelschafer-Crabb, G., Kennedy, W. R., ... Dougherty, P. M. (2012). Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. Clinical Cancer Research, 18(11), 3180-3187. https://doi.org/10.1158/1078-0432.CCR-12-0205

Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. / Boyette-Davis, Jessica A.; Eng, Cathy; Wang, Xin S.; Cleeland, Charles S.; Wendelschafer-Crabb, Gwen; Kennedy, William R; Simone, Donald A; Zhang, Haijun; Dougherty, Patrick M.

In: Clinical Cancer Research, Vol. 18, No. 11, 01.06.2012, p. 3180-3187.

Research output: Contribution to journalArticle

Boyette-Davis, JA, Eng, C, Wang, XS, Cleeland, CS, Wendelschafer-Crabb, G, Kennedy, WR, Simone, DA, Zhang, H & Dougherty, PM 2012, 'Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy', Clinical Cancer Research, vol. 18, no. 11, pp. 3180-3187. https://doi.org/10.1158/1078-0432.CCR-12-0205
Boyette-Davis, Jessica A. ; Eng, Cathy ; Wang, Xin S. ; Cleeland, Charles S. ; Wendelschafer-Crabb, Gwen ; Kennedy, William R ; Simone, Donald A ; Zhang, Haijun ; Dougherty, Patrick M. / Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy. In: Clinical Cancer Research. 2012 ; Vol. 18, No. 11. pp. 3180-3187.
@article{13f2d170a5d34004a905f6c4193c4f6b,
title = "Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy",
abstract = "Purpose: Of the numerous complications associated with cancer and cancer treatment, peripheral neuropathy is a deleterious and persistent patient complaint commonly attributed to chemotherapy. The present study investigated the occurrence of subclinical peripheral neuropathy in patients with colorectal cancer before the initiation of chemotherapy. Experimental Design: Fifty-two patients underwent extensive quantitative sensory testing (QST) before receiving chemotherapy. Changes in multiple functions of primary afferent fibers were assessed and compared with a group of healthy control subjects. Skin temperature, sensorimotor function, sharpness detection, and thermal detection were measured, as was touch detection, using both conventional (von Frey monofilaments) and novel (Bumps detection test) methodology. Results: Patients had subclinical deficits, especially in sensorimotor function, detection of thermal stimuli, and touch detection that were present before the initiation of chemotherapy. The measured impairment in touch sensation was especially pronounced when using the Bumps detection test. Conclusions: The patients with colorectal cancer in this study exhibited deficits in sensory function before undergoing chemotherapy treatment, implicating the disease itself as a contributing factor in chemotherapy-induced peripheral neuropathy. The widespread nature of the observed deficits further indicated that cancer is affecting multiple primary afferent subtypes. Specific to the finding of impaired touch sensation, results from this study highlight the use of newly used methodology, the Bumps detection test, as a sensitive and useful tool in the early detection of peripheral neuropathy.",
author = "Boyette-Davis, {Jessica A.} and Cathy Eng and Wang, {Xin S.} and Cleeland, {Charles S.} and Gwen Wendelschafer-Crabb and Kennedy, {William R} and Simone, {Donald A} and Haijun Zhang and Dougherty, {Patrick M.}",
year = "2012",
month = "6",
day = "1",
doi = "10.1158/1078-0432.CCR-12-0205",
language = "English (US)",
volume = "18",
pages = "3180--3187",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "11",

}

TY - JOUR

T1 - Subclinical peripheral neuropathy is a common finding in colorectal cancer patients prior to chemotherapy

AU - Boyette-Davis, Jessica A.

AU - Eng, Cathy

AU - Wang, Xin S.

AU - Cleeland, Charles S.

AU - Wendelschafer-Crabb, Gwen

AU - Kennedy, William R

AU - Simone, Donald A

AU - Zhang, Haijun

AU - Dougherty, Patrick M.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Purpose: Of the numerous complications associated with cancer and cancer treatment, peripheral neuropathy is a deleterious and persistent patient complaint commonly attributed to chemotherapy. The present study investigated the occurrence of subclinical peripheral neuropathy in patients with colorectal cancer before the initiation of chemotherapy. Experimental Design: Fifty-two patients underwent extensive quantitative sensory testing (QST) before receiving chemotherapy. Changes in multiple functions of primary afferent fibers were assessed and compared with a group of healthy control subjects. Skin temperature, sensorimotor function, sharpness detection, and thermal detection were measured, as was touch detection, using both conventional (von Frey monofilaments) and novel (Bumps detection test) methodology. Results: Patients had subclinical deficits, especially in sensorimotor function, detection of thermal stimuli, and touch detection that were present before the initiation of chemotherapy. The measured impairment in touch sensation was especially pronounced when using the Bumps detection test. Conclusions: The patients with colorectal cancer in this study exhibited deficits in sensory function before undergoing chemotherapy treatment, implicating the disease itself as a contributing factor in chemotherapy-induced peripheral neuropathy. The widespread nature of the observed deficits further indicated that cancer is affecting multiple primary afferent subtypes. Specific to the finding of impaired touch sensation, results from this study highlight the use of newly used methodology, the Bumps detection test, as a sensitive and useful tool in the early detection of peripheral neuropathy.

AB - Purpose: Of the numerous complications associated with cancer and cancer treatment, peripheral neuropathy is a deleterious and persistent patient complaint commonly attributed to chemotherapy. The present study investigated the occurrence of subclinical peripheral neuropathy in patients with colorectal cancer before the initiation of chemotherapy. Experimental Design: Fifty-two patients underwent extensive quantitative sensory testing (QST) before receiving chemotherapy. Changes in multiple functions of primary afferent fibers were assessed and compared with a group of healthy control subjects. Skin temperature, sensorimotor function, sharpness detection, and thermal detection were measured, as was touch detection, using both conventional (von Frey monofilaments) and novel (Bumps detection test) methodology. Results: Patients had subclinical deficits, especially in sensorimotor function, detection of thermal stimuli, and touch detection that were present before the initiation of chemotherapy. The measured impairment in touch sensation was especially pronounced when using the Bumps detection test. Conclusions: The patients with colorectal cancer in this study exhibited deficits in sensory function before undergoing chemotherapy treatment, implicating the disease itself as a contributing factor in chemotherapy-induced peripheral neuropathy. The widespread nature of the observed deficits further indicated that cancer is affecting multiple primary afferent subtypes. Specific to the finding of impaired touch sensation, results from this study highlight the use of newly used methodology, the Bumps detection test, as a sensitive and useful tool in the early detection of peripheral neuropathy.

UR - http://www.scopus.com/inward/record.url?scp=84861777271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861777271&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-12-0205

DO - 10.1158/1078-0432.CCR-12-0205

M3 - Article

VL - 18

SP - 3180

EP - 3187

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 11

ER -