Subclinical high-resolution chest CT scan features in psoriasis

Shaher M. Samrah, Firas Qarqaz, Omar Obeidat, Zineb Bataineh, Anoud Ramadan, Ghid Al Zubaidi, Mustafa Alwani, Dina Abualnaaj, Faris J. Abu Za'nouneh, Hassan Al-Balas, Yassmen Almomani, Randa S. Samrah, Aahd F. Kubbara, Basheer Y. Khassawneh

Research output: Contribution to journalArticlepeer-review


Background: Although psoriasis is considered a systemic disease, no clear association has been established between psoriasis and lung diseases. This study aims to detect and describe subclinical pulmonary involvement in psoriasis patients with various degrees of cutaneous manifestations. Methods: Adult psoriasis patients with no known active pulmonary disease or respiratory symptoms were screened for subclinical pulmonary manifestations and possible parenchymal changes using high-resolution computed tomography (HRCT) scan of the chest. Patients were classified according to the severity of skin manifestations. The clinical characteristics and radiographic findings of these patients were evaluated. Results: Fifty-nine patients with psoriasis were included, among which 47 (79.7%) had abnormal HRCT scan features. Micronodules were the most common detected lung lesions (66.1%), followed by nonspecific interstitial changes (32.2%), including pleuro-parenchymal band/atelectasis, scarring, and focal ground-glass opacities. Other HRCT findings included emphysematous changes and calcified granulomas. Abnormal HRCT findings correlated with older age and duration of psoriasis but not with the severity of skin manifestations. Conclusions: Micronodules and minor focal nonspecific interstitial changes were the most detected lung alterations in patients with psoriasis. These findings of the pilot study highlight a possible pulmonary involvement in patients with psoriasis. Larger multicenter studies are needed to clarify these findings further. Limitations: A major limitation of the study, is the lack of a control group with similar radiologic findings of different conditions done in the same geographical region.

Original languageEnglish (US)
Article number107226
JournalRespiratory Medicine
StatePublished - Jun 2023
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant from the Deanship of Research at Jordan University of Science and Technology, Irbid, Jordan . The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

Publisher Copyright:
© 2023 Elsevier Ltd


  • CT scan
  • Interstitial lung disease
  • Nodules
  • Psoriasis
  • Pulmonary

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't


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