Subclinical cardiovascular disease markers applicable to studies of oral health: Multiethnic study of atherosclerosis

David R Jacobs Jr, Richard S. Crow

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Scopus citations


Recent findings associate periodontal disease with established coronary heart disease (CHD) and with disorders of the carotid artery. Besides measures of the carotid artery, a number of other noninvasive subclinical markers of cardiovascular disease exist and are summarized here. Included are computed tomography (CT) of the coronary arteries, ultrasound of the carotid arteries, echocardiography, magnetic resonance imaging (MRI), ankle-brachial index, microalbuminuria, and other biochemical measures of kidney dysfunction, flow-mediated dilation in the brachial artery, and pulse wave form analysis. Use of these measures may simplify and add depth to studies of oral health and cardiovascular disease. However, it is noted that the measures are not highly correlated with each other (based on 6,814 persons in the Multiethnic Study of Atherosclerosis, Pearson correlations among the above subclinical measures, range from about 0.1-0.4), do not include propensity for the important atherosclerotic phase of plaque rupture, and do not fully substitute for studies of clinical cardiovascular disease endpoints.

Original languageEnglish (US)
Title of host publicationOral-based Diagnostics
PublisherBlackwell Publishing Inc
Number of pages19
ISBN (Print)157331661X, 9781573316613
StatePublished - Mar 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Ankle-brachial index
  • Carotid artery wall thickness
  • Coronary calcium
  • Magnetic resonance imaging
  • Periodontitis
  • Urinary albumin


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