Subclinical cardiovascular disease and changes in self-reported mobility

Multi-ethnic study of atherosclerosis

Susan Everson-Rose, Carlos F. Mendes de Leon, Nicholas S. Roetker, Pamela L Lutsey, Alvaro Alonso

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We examined associations of three markers of subclinical cardiovascular disease (intimal-medial thickening, coronary artery calcification, and ankle-brachial index) with changes in self-reported walking over time. Methods: Data were from 6,490 Multi-Ethnic Study of Atherosclerosis participants (aged 45–84 years), free of clinical cardiovascular disease at baseline. Outcomes, assessed four times over 11 years, included self-reported walking pace (none to striding pace; score, 0–4) and total walking time (minutes/week). Linear generalized estimating equation models estimated associations of baseline intimal-medial thickening (zscored), coronary artery calcification (Agatston units), and ankle-brachial index (ratio of ankle-to-arm systolic blood pressure) with walking pace and walking time modeled continuously in separate analyses. Results: Median follow-up was 9.2 years (maximum, 11.4). Walking pace (estimate, −0.042 points [95% CI; −0.048, −0.036], p < 0.0001) and walking time (estimate, −4.71 minutes [95% CI: −8.54, −0.88], p = 0.016) decreased yearly. Greater baseline intimal-medial thickening related to faster decline in walking pace in multivariable analyses: walking pace score decreased 0.004 points (95% CI: −0.008, −0.001) more per year for each 1-SD higher intimal-medial thickening z-score, equivalent to an additional 10% slower yearly walking. Greater coronary artery calcification was associated with slower walking but inconsistently related to decline in walking pace. Higher ankle-brachial index was associated with faster baseline walking pace (estimate, 0.043 points [95% CI: 0.027, 0.059] per 1-SD) but unrelated to changes in walking pace. Cardiovascular disease measures were unrelated to total walking time. Conclusions: Greater subclinical cardiovascular disease is associated with prevalent slower self-reported walking pace in middle-aged and older adults but has limited impact on changes in walking over time.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume73
Issue number2
DOIs
StatePublished - Mar 1 2018

Fingerprint

Atherosclerosis
Walking
Cardiovascular Diseases
Tunica Intima
Ankle Brachial Index
Coronary Vessels
Blood Pressure
Walking Speed
Ankle
Arm

Keywords

  • Cardiovascular
  • Epidemiology—Risk
  • Factors.
  • Physical function

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Subclinical cardiovascular disease and changes in self-reported mobility : Multi-ethnic study of atherosclerosis. / Everson-Rose, Susan; Mendes de Leon, Carlos F.; Roetker, Nicholas S.; Lutsey, Pamela L; Alonso, Alvaro.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 73, No. 2, 01.03.2018, p. 218-224.

Research output: Contribution to journalArticle

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abstract = "Background: We examined associations of three markers of subclinical cardiovascular disease (intimal-medial thickening, coronary artery calcification, and ankle-brachial index) with changes in self-reported walking over time. Methods: Data were from 6,490 Multi-Ethnic Study of Atherosclerosis participants (aged 45–84 years), free of clinical cardiovascular disease at baseline. Outcomes, assessed four times over 11 years, included self-reported walking pace (none to striding pace; score, 0–4) and total walking time (minutes/week). Linear generalized estimating equation models estimated associations of baseline intimal-medial thickening (zscored), coronary artery calcification (Agatston units), and ankle-brachial index (ratio of ankle-to-arm systolic blood pressure) with walking pace and walking time modeled continuously in separate analyses. Results: Median follow-up was 9.2 years (maximum, 11.4). Walking pace (estimate, −0.042 points [95{\%} CI; −0.048, −0.036], p < 0.0001) and walking time (estimate, −4.71 minutes [95{\%} CI: −8.54, −0.88], p = 0.016) decreased yearly. Greater baseline intimal-medial thickening related to faster decline in walking pace in multivariable analyses: walking pace score decreased 0.004 points (95{\%} CI: −0.008, −0.001) more per year for each 1-SD higher intimal-medial thickening z-score, equivalent to an additional 10{\%} slower yearly walking. Greater coronary artery calcification was associated with slower walking but inconsistently related to decline in walking pace. Higher ankle-brachial index was associated with faster baseline walking pace (estimate, 0.043 points [95{\%} CI: 0.027, 0.059] per 1-SD) but unrelated to changes in walking pace. Cardiovascular disease measures were unrelated to total walking time. Conclusions: Greater subclinical cardiovascular disease is associated with prevalent slower self-reported walking pace in middle-aged and older adults but has limited impact on changes in walking over time.",
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T1 - Subclinical cardiovascular disease and changes in self-reported mobility

T2 - Multi-ethnic study of atherosclerosis

AU - Everson-Rose, Susan

AU - Mendes de Leon, Carlos F.

AU - Roetker, Nicholas S.

AU - Lutsey, Pamela L

AU - Alonso, Alvaro

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N2 - Background: We examined associations of three markers of subclinical cardiovascular disease (intimal-medial thickening, coronary artery calcification, and ankle-brachial index) with changes in self-reported walking over time. Methods: Data were from 6,490 Multi-Ethnic Study of Atherosclerosis participants (aged 45–84 years), free of clinical cardiovascular disease at baseline. Outcomes, assessed four times over 11 years, included self-reported walking pace (none to striding pace; score, 0–4) and total walking time (minutes/week). Linear generalized estimating equation models estimated associations of baseline intimal-medial thickening (zscored), coronary artery calcification (Agatston units), and ankle-brachial index (ratio of ankle-to-arm systolic blood pressure) with walking pace and walking time modeled continuously in separate analyses. Results: Median follow-up was 9.2 years (maximum, 11.4). Walking pace (estimate, −0.042 points [95% CI; −0.048, −0.036], p < 0.0001) and walking time (estimate, −4.71 minutes [95% CI: −8.54, −0.88], p = 0.016) decreased yearly. Greater baseline intimal-medial thickening related to faster decline in walking pace in multivariable analyses: walking pace score decreased 0.004 points (95% CI: −0.008, −0.001) more per year for each 1-SD higher intimal-medial thickening z-score, equivalent to an additional 10% slower yearly walking. Greater coronary artery calcification was associated with slower walking but inconsistently related to decline in walking pace. Higher ankle-brachial index was associated with faster baseline walking pace (estimate, 0.043 points [95% CI: 0.027, 0.059] per 1-SD) but unrelated to changes in walking pace. Cardiovascular disease measures were unrelated to total walking time. Conclusions: Greater subclinical cardiovascular disease is associated with prevalent slower self-reported walking pace in middle-aged and older adults but has limited impact on changes in walking over time.

AB - Background: We examined associations of three markers of subclinical cardiovascular disease (intimal-medial thickening, coronary artery calcification, and ankle-brachial index) with changes in self-reported walking over time. Methods: Data were from 6,490 Multi-Ethnic Study of Atherosclerosis participants (aged 45–84 years), free of clinical cardiovascular disease at baseline. Outcomes, assessed four times over 11 years, included self-reported walking pace (none to striding pace; score, 0–4) and total walking time (minutes/week). Linear generalized estimating equation models estimated associations of baseline intimal-medial thickening (zscored), coronary artery calcification (Agatston units), and ankle-brachial index (ratio of ankle-to-arm systolic blood pressure) with walking pace and walking time modeled continuously in separate analyses. Results: Median follow-up was 9.2 years (maximum, 11.4). Walking pace (estimate, −0.042 points [95% CI; −0.048, −0.036], p < 0.0001) and walking time (estimate, −4.71 minutes [95% CI: −8.54, −0.88], p = 0.016) decreased yearly. Greater baseline intimal-medial thickening related to faster decline in walking pace in multivariable analyses: walking pace score decreased 0.004 points (95% CI: −0.008, −0.001) more per year for each 1-SD higher intimal-medial thickening z-score, equivalent to an additional 10% slower yearly walking. Greater coronary artery calcification was associated with slower walking but inconsistently related to decline in walking pace. Higher ankle-brachial index was associated with faster baseline walking pace (estimate, 0.043 points [95% CI: 0.027, 0.059] per 1-SD) but unrelated to changes in walking pace. Cardiovascular disease measures were unrelated to total walking time. Conclusions: Greater subclinical cardiovascular disease is associated with prevalent slower self-reported walking pace in middle-aged and older adults but has limited impact on changes in walking over time.

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