Subacute infantile mountain sickness

G. J. Sui, Y. H. Liu, X. S. Cheng, I. S. Anand, E. Harris, P. Harris, D. Heath

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

A description is given of a disease of infants occurring in Lhasa, Tibet at an altitude of 3600m. Typically it affects infants who have been born at low altitude and subsequently brought to reside in Lhasa, and it is usually fatal within a few weeks or months. There is extreme medial hypertrophy of muscular pulmonary arteries and muscularization of pulmonary arterioles, together with dilatation of the pulmonary trunk and massive hypertrophy and dilatation of the right ventricle. The disease is distinct from acute or chronic mountain sickness and appears to be the human counterpart of ‘brisket disease’ in cattle.

Original languageEnglish (US)
Pages (from-to)161-170
Number of pages10
JournalThe Journal of Pathology
Volume155
Issue number2
DOIs
StatePublished - Jun 1988

Keywords

  • Mountain sickness
  • Tibet
  • high altitude
  • hypoxia
  • pulmonary hypertension
  • pulmonary vascular disease

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