Studying tauopathies in Drosophila: A fruitful model

Mingkuan Sun; Liam Chen

doi:10.1016/j.expneurol.2015.03.029

Studying tauopathies in Drosophila: A fruitful model

Mingkuan Sun, Liam Chen

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Tauopathies are a group of neurodegenerative disorders that include hereditary frontotemporal dementias (FTDs) such as FTD with parkinsonism linked to chromosome 17 (FTDP-17), as well as sporadic variants of FTDs like progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease. These diverse diseases all have in common the presence of abnormally phosphorylated tau aggregates. In this review, we will summarize key features of transgenic Drosophila models of tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from the fruit fly models.

Original language	English (US)
Pages (from-to)	52-57
Number of pages	6
Journal	Experimental Neurology
Volume	274
DOIs	https://doi.org/10.1016/j.expneurol.2015.03.029
State	Published - Dec 1 2015
Externally published	Yes

Bibliographical note

Funding Information:
M.S. and L.C. are supported by the Robert Packard Center at Johns Hopkins , and by the McKnight Endowment Fund for Neuroscience .

Publisher Copyright:
© 2015 Elsevier Inc.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Drosophila
Frontotemporal dementia
Tau
Tauopathy

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10.1016/j.expneurol.2015.03.029

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abstract = "Tauopathies are a group of neurodegenerative disorders that include hereditary frontotemporal dementias (FTDs) such as FTD with parkinsonism linked to chromosome 17 (FTDP-17), as well as sporadic variants of FTDs like progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease. These diverse diseases all have in common the presence of abnormally phosphorylated tau aggregates. In this review, we will summarize key features of transgenic Drosophila models of tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from the fruit fly models.",

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AU - Chen, Liam

N1 - Funding Information: M.S. and L.C. are supported by the Robert Packard Center at Johns Hopkins , and by the McKnight Endowment Fund for Neuroscience . Publisher Copyright: © 2015 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

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N2 - Tauopathies are a group of neurodegenerative disorders that include hereditary frontotemporal dementias (FTDs) such as FTD with parkinsonism linked to chromosome 17 (FTDP-17), as well as sporadic variants of FTDs like progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease. These diverse diseases all have in common the presence of abnormally phosphorylated tau aggregates. In this review, we will summarize key features of transgenic Drosophila models of tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from the fruit fly models.

AB - Tauopathies are a group of neurodegenerative disorders that include hereditary frontotemporal dementias (FTDs) such as FTD with parkinsonism linked to chromosome 17 (FTDP-17), as well as sporadic variants of FTDs like progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and Pick's disease. These diverse diseases all have in common the presence of abnormally phosphorylated tau aggregates. In this review, we will summarize key features of transgenic Drosophila models of tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from the fruit fly models.

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Studying tauopathies in Drosophila: A fruitful model

Abstract

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