Study Protocol: Multimodal Longitudinal Assessment of Infant Brain Organization and Recovery in Perinatal Brain Injury

Catarina Saiote, Ellen Sutter, Annette Xenopoulos-Oddsson, Raghavendra Rao, Michael Georgieff, Kyle Rudser, Colleen Peyton, Douglas Dean, Ryan M. McAdams, Bernadette Gillick

Research output: Contribution to journalArticlepeer-review


Purpose: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood. Methods: Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to noninvasively measure CST functional and structural integrity across multiple time points in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function. Discussion: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.

Original languageEnglish (US)
Pages (from-to)268-276
Number of pages9
JournalPediatric Physical Therapy
Issue number2
StatePublished - Apr 1 2022

Bibliographical note

Funding Information:
Grant Support: This work was supported in part by a Promotion of Doctoral Studies I Scholarship from the Foundation for Physical Therapy Research and by the Shepherd Family Trust.

Funding Information:
Grant Support: This work is supported by the National Institute of Child Health and Human Development/National Institute of Neurological Disorders and Stroke (7R01HD098202-02).

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.


  • cerebral palsy
  • infant
  • magnetic resonance imaging
  • movement assessment
  • perinatal stroke
  • transcranial magnetic stimulation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural


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