A random (r1r2 — 1) hydrophilic/hydrophobic copolymer of methyl methacrylate and acrylamide has been prepared and characterized. Fractions prepared by the fractional precipitation method are characterized in terms of molecular weight, second virial coefficient, intrinsic viscosity, and diffusion coefficient. Equivalent hard sphere radii are calculated, and the ratios between different radii are compared to those of homopolymers. Molecular weight dependencies of the second virial coefficient, intrinsic viscosity, and diffusion coefficient are also examined, The results indicate that random copolymers made of very different comonomers behave similarly, in their scaling behavior, to homopoly-mers, although these results are somewhat inconclusive due to the narrow range and relatively low values of molecular weight investigated.
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This work was supported by the Schering-Plough Foundation and the California Biotechnology Research & Education Program. We are grateful to Dr. Morton Denn at UC Berkeley who made it possible to use the dynamic light-scattering system.
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