Study of systemic lupus erythematosus in temporal bones

Michihiko Sone, Michael M. Paparella, Patricia A. Schachern, Noriko Morizono

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Despite some reports of sensorineural hearing loss with systemic lupus erythematosus (SLE), its pathologic correlate has remained unidentified due to the scarcity of human temporal bone studies. We here present findings in 14 temporal bones from 7 patients with SLE, examined histologically and immunohistochemically for pathologic conditions in the cochlea that might relate to their otologic histories. Blue-staining concretions were seen in the stria vascularis of 6 ears. Most of the cases showed a loss of spiral ganglion cells, with various degrees of hair cell loss and atrophy of the stria vascularis. One ear demonstrated formation of fibrous tissue and bone throughout the cochlea, with complete loss of the membranous labyrinth. Cochlear hydrops was found in only 1 ear. These findings in temporal bones from patients with SLE are discussed in relation to autoimmune disease of the inner ear.

Original languageEnglish (US)
Pages (from-to)338-344
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume108
Issue number4 I
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Autoimmune disease
  • Histopathology
  • Human temporal bone
  • Systemic lupus erythematosus

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