Studies toward the Synthesis of Oximidines I and II

Torsten Haack, Serdar Kurtkaya, James P. Snyder, Gunda I. Georg

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

(Equation presented) The synthesis of compound 1, a precursor for the synthesis of the oximidine II core structure 2, is described. An undesired C8-C9 isomerization occurred during the intramolecular Castro-Stephens reaction leading to macrocyle 3. The thermodynamic driving force for this unexpected isomerization was established by DFT and MP2 calculations.

Original languageEnglish (US)
Pages (from-to)5019-5022
Number of pages4
JournalOrganic Letters
Volume5
Issue number26
DOIs
StatePublished - Dec 25 2003

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