Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

U. Hornemann; J. C. Cloyd

doi:10.1039/C29710000301

Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

U. Hornemann, J. C. Cloyd

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me-^-14C-L-methionine and guanido- ¹⁴C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C₆-fragment of these antibiotics.

Original language	English (US)
Pages (from-to)	301-302
Number of pages	2
Journal	Journal of the Chemical Society D: Chemical Communications
Issue number	7
DOIs	https://doi.org/10.1039/C29710000301
State	Published - 1971

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title = "Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus",

abstract = "Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me--14C-L-methionine and guanido- 14C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C6-fragment of these antibiotics.",

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year = "1971",

doi = "10.1039/C29710000301",

language = "English (US)",

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journal = "Journal of the Chemical Society D: Chemical Communications",

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publisher = "Royal Society of Chemistry",

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AU - Hornemann, U.

AU - Cloyd, J. C.

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AB - Biosynthetic studies indicate that the mitomycins are not formed from aromatic precursors, but that Me--14C-L-methionine and guanido- 14C-L-arginine specifically label peripheral substituents and that glucosamine is probably incorporated intact into a C6-fragment of these antibiotics.

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Studies on the biosynthesis of the mitomycin antibiotics by Streptomyces verticillatus

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