Studies on circadian periodicity of urinary corticoids in carcinoma of the breast

R. Singh, R. K. Singh, A. A. Mahdi, S. Misra, S. P. Rai, D. Singh, G. Cornélissen, F. Halberg

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The circadian periodicity of urinary 17-ketogenic steroids (17-KGS), 17-ketosteroids (17-KS) and a creatinine (Cr) was studied preoperatively and on the 9th postoperative day in 25 histopathologically proved breast cancer patients and in 15 healthy Indian women under tropical conditions. A statistically significant rhythm was observed in healthy participants for all three variables. Urinary corticoids were markedly elevated in breast cancer patients irrespective of the stage of the disease in comparison with healthy controls. The degree of elevation was more pronounced preoperatively in advanced stage breast cancer in comparison with other groups. After mastectomy, the values of all three variables declined markedly, approaching usual values with a circadian rhythm resembling the pattern found in clinical health.

Original languageEnglish (US)
Pages (from-to)69-73
Number of pages5
JournalIn Vivo
Issue number1
StatePublished - 1998


  • Breasr cancer
  • Circadian
  • Mastectomy
  • Tropical conditions
  • Urinary corticoids


Dive into the research topics of 'Studies on circadian periodicity of urinary corticoids in carcinoma of the breast'. Together they form a unique fingerprint.

Cite this