| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-181 |
| Number of pages | 5 |
| Journal | Seminars in Colon and Rectal Surgery |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2006 |
Bibliographical note
Funding Information:I graduated from Hiroshima University School of Medicine in 1991. After five years of surgical training, I started colorectal surgery training in the University hospital. The major part of my clinical work was spent on the surgical treatment of inflammatory bowel diseases. I came to the US in 2002, funded by The Japan Antibiotic Research Association. In Minneapolis, I worked with Dr. Robert Madoff (a colorectal surgeon) and Dr. Michael Levitt (a gastroenterologist) on the gas research. In the second year of my stay in the US, I was awarded an American Society of Colon and Rectal Surgeons Research Fellowship to study the possibility that the highly toxic bacterial product, hydrogen sulfide (H 2 S), plays a pathogenetic role in pouchitis. These studies demonstrated that (1) H 2 S production was about 10 times greater by pouch contents of subjects whose pouches were created following colectomy for ulcerative colitis (UC) versus those created for familial adenomatous polyposis (FAP); and (2) H 2 S production was greatest in subjects with ongoing or recent pouchitis. We concluded that there is a difference in the H 2 S producing propensity of fecal contents of UC versus FAP, which is particularly pronounced in subjects with acute pouchitis. I believe that this work has a valuable implication that H 2 S could be involved in the pathogenesis of pouchitis, and that there may be a fundamental difference in the bacterial metabolism of UC subjects versus those with FAP that could play a role UC pathogenesis. This Fellowship provided me with an invaluable education in the biochemistry, bacteriology, and analytical techniques involved in the research of H 2 S metabolism. This work helped to establish my academic standing in Japan and has allowed me to initiate an independent research career.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.