Bibliographical noteFunding Information:
I graduated from Hiroshima University School of Medicine in 1991. After five years of surgical training, I started colorectal surgery training in the University hospital. The major part of my clinical work was spent on the surgical treatment of inflammatory bowel diseases. I came to the US in 2002, funded by The Japan Antibiotic Research Association. In Minneapolis, I worked with Dr. Robert Madoff (a colorectal surgeon) and Dr. Michael Levitt (a gastroenterologist) on the gas research. In the second year of my stay in the US, I was awarded an American Society of Colon and Rectal Surgeons Research Fellowship to study the possibility that the highly toxic bacterial product, hydrogen sulfide (H 2 S), plays a pathogenetic role in pouchitis. These studies demonstrated that (1) H 2 S production was about 10 times greater by pouch contents of subjects whose pouches were created following colectomy for ulcerative colitis (UC) versus those created for familial adenomatous polyposis (FAP); and (2) H 2 S production was greatest in subjects with ongoing or recent pouchitis. We concluded that there is a difference in the H 2 S producing propensity of fecal contents of UC versus FAP, which is particularly pronounced in subjects with acute pouchitis. I believe that this work has a valuable implication that H 2 S could be involved in the pathogenesis of pouchitis, and that there may be a fundamental difference in the bacterial metabolism of UC subjects versus those with FAP that could play a role UC pathogenesis. This Fellowship provided me with an invaluable education in the biochemistry, bacteriology, and analytical techniques involved in the research of H 2 S metabolism. This work helped to establish my academic standing in Japan and has allowed me to initiate an independent research career.
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