Studies of feedback suppression of bile salt synthesis in the bile-fistula rat

William C Duane, A. P. McHale, J. N. Hamilton

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10 Scopus citations

Abstract

We have previously reported that intravenous infusion of taurocholate at 10 μmol/(100 g. hr) into bile-fistula rats suppressed bile salt synthesis by 85% (Pries et al. 1983. J. Lipid Res. 24: 141-146). Recently, however, infusion rates twice this high have been reported not to suppress synthesis (Davis et al. 1984. Falk Symposium 42. MTP Press Ltd., Boston, 37-45). Because the only major difference in design of these two studies was supplementation with sodium bicarbonate to replace biliary losses induced by bile salt choleresis, we have repeated our studies with and without bicarbonate supplementation. Without bicarbonate, as before, we found suppression of synthesis during infusion of taurocholate at 10 μmol/(100 g·hr). With bicarbonate, no suppression of synthesis occurred at these infusion rates. These data indicate that bicarbonate supplementation is essential when testing physiological effects of infused bile salt in the bile-fistula rat.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalJournal of Lipid Research
Volume29
Issue number2
StatePublished - Jan 1 1988
Externally publishedYes

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