TY - JOUR
T1 - Structures and biological activities of novel antibiotic peptaibols neoatroviridins A-D from Trichoderma atroviride F80317
AU - Oh, Seung Uk
AU - Yun, Bong Sik
AU - Lee, Sang Jun
AU - Yoo, Ick Dong
PY - 2005/4/1
Y1 - 2005/4/1
N2 - Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.
AB - Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.
KW - Membrane-perturbing activity
KW - Neoatroviridins
KW - Peptaibol antibiotic
KW - Structure determination
KW - Trichoderma atroviride
UR - http://www.scopus.com/inward/record.url?scp=18144373515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=18144373515&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:18144373515
SN - 1017-7825
VL - 15
SP - 384
EP - 387
JO - Journal of Microbiology and Biotechnology
JF - Journal of Microbiology and Biotechnology
IS - 2
ER -