Structure of Toxic Shock Syndrome Toxin 1

G. Sridhar Prasad, Cathleen A. Earhart, Debra L. Murray, Richard P. Novick, Patrick M. Schlievert, Douglas H. Ohlendorf

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


The three-dimensional structure of toxic shock syndrome toxin 1 (TSST-1) from Staphylococcus aureus has been determined and refined to an R value of 0.226 for data between 8- and 2.5-Å resolution. Overall, the structure of TSST-1 is similar to that of another superantigen, staphylococcal enterotoxin B (SEB). The key differences between these molecules are in the amino termini and in the degree to which a long central helix is covered by surface loops. The region around the carboxyl end of this central helix is proposed to govern the superantigenic properties of TSST-1. An adjacent region along this helix is proposed to be critical in the ability of TSST-1 to induce toxic shock syndrome.

Original languageEnglish (US)
Pages (from-to)13761-13766
Number of pages6
Issue number50
StatePublished - Dec 21 1993


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