Structure of the ATP-synthase studied by electron microscopy and image processing

Vladimir L. Tsuprun, Elena V. Orlova, Irina V. Mesyanzhinova

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The structure of ATP synthase from beef heart mitochondria has been studied by electron microscopy and image processing using negatively stained specimens of detergent-solubilized and membrane-bound molecules. The F1-ATPase and the membrane-embedded F0 sector of ATP synthase are found to be connected by a narrow stalk, 4-4.5 nm long and 3-3.5 nm wide, projecting about 4.2 nm from the membrane surface. The F0 sector has a globular shape, 6-8 nm in diameter and, in part, extends from the membrane lipid bilayer.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalFEBS Letters
Volume244
Issue number2
DOIs
StatePublished - Feb 27 1989

Keywords

  • ATP synthase
  • Electron microscopy
  • Enzyme structure

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