Structure of Seneca Valley Virus-001: An Oncolytic Picornavirus Representing a New Genus

Sangita Venkataraman; Seshidhar P. Reddy; Jackie Loo; Neeraja Idamakanti; Paul L. Hallenbeck; Vijay S. Reddy

doi:10.1016/j.str.2008.07.013

Structure of Seneca Valley Virus-001: An Oncolytic Picornavirus Representing a New Genus

Sangita Venkataraman, Seshidhar P. Reddy, Jackie Loo, Neeraja Idamakanti, Paul L. Hallenbeck, Vijay S. Reddy

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

The crystal structure of Seneca Valley Virus-001 (SVV-001), the representative member of a new genus, Senecavirus, is reported at 2.3Å resolution. SVV-001 is the first naturally occurring nonpathogenic picornavirus shown to mediate selective cytotoxicity towards tumor cells with neuroendocrine cancer features. The nonsegmented (+) ssRNA genome of SVV-001 shares closest sequence similarity with the genomes of the members of Cardiovirus. The overall tertiary structure of VP1-VP4 subunits is conserved with the exception of loops, especially those of VP1 that show large deviations relative to the members of the cardioviruses. The surface loops of VP1 and VP2 are predicted to mediate cell tropism of SVV-001. In addition, the organization of the packaged nucleic acid density indicates that certain regions of VP2 and VP4 interact closely with the packaged nucleic acid.

Original language	English (US)
Pages (from-to)	1555-1561
Number of pages	7
Journal	Structure
Volume	16
Issue number	10
DOIs	https://doi.org/10.1016/j.str.2008.07.013
State	Published - Oct 8 2008
Externally published	Yes

Bibliographical note

Funding Information:
We are extremely grateful for the assistance and help of the staff at the BIOCARS facility, Vukica Srajer, Reinhard Pahl, and Spencer Anderson in setting up the experiment under the BSL2 conditions. This work was partially supported by the National Institutes of Health (NIH) Grant R56 AI070771 to V.S.R. Partial salary support to V.S.R. by NIH Research Resource Multiscale Modeling Tools for Structural Biology (MMTSB; RR12255) is acknowledged.

Keywords

EVO_ECOL
MICROBIO

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.str.2008.07.013

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abstract = "The crystal structure of Seneca Valley Virus-001 (SVV-001), the representative member of a new genus, Senecavirus, is reported at 2.3{\AA} resolution. SVV-001 is the first naturally occurring nonpathogenic picornavirus shown to mediate selective cytotoxicity towards tumor cells with neuroendocrine cancer features. The nonsegmented (+) ssRNA genome of SVV-001 shares closest sequence similarity with the genomes of the members of Cardiovirus. The overall tertiary structure of VP1-VP4 subunits is conserved with the exception of loops, especially those of VP1 that show large deviations relative to the members of the cardioviruses. The surface loops of VP1 and VP2 are predicted to mediate cell tropism of SVV-001. In addition, the organization of the packaged nucleic acid density indicates that certain regions of VP2 and VP4 interact closely with the packaged nucleic acid.",

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note = "Funding Information: We are extremely grateful for the assistance and help of the staff at the BIOCARS facility, Vukica Srajer, Reinhard Pahl, and Spencer Anderson in setting up the experiment under the BSL2 conditions. This work was partially supported by the National Institutes of Health (NIH) Grant R56 AI070771 to V.S.R. Partial salary support to V.S.R. by NIH Research Resource Multiscale Modeling Tools for Structural Biology (MMTSB; RR12255) is acknowledged. ",

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AU - Hallenbeck, Paul L.

AU - Reddy, Vijay S.

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PY - 2008/10/8

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N2 - The crystal structure of Seneca Valley Virus-001 (SVV-001), the representative member of a new genus, Senecavirus, is reported at 2.3Å resolution. SVV-001 is the first naturally occurring nonpathogenic picornavirus shown to mediate selective cytotoxicity towards tumor cells with neuroendocrine cancer features. The nonsegmented (+) ssRNA genome of SVV-001 shares closest sequence similarity with the genomes of the members of Cardiovirus. The overall tertiary structure of VP1-VP4 subunits is conserved with the exception of loops, especially those of VP1 that show large deviations relative to the members of the cardioviruses. The surface loops of VP1 and VP2 are predicted to mediate cell tropism of SVV-001. In addition, the organization of the packaged nucleic acid density indicates that certain regions of VP2 and VP4 interact closely with the packaged nucleic acid.

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Structure of Seneca Valley Virus-001: An Oncolytic Picornavirus Representing a New Genus

Abstract

Bibliographical note

Keywords

UN SDGs

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