Abstract
Synthetic glucocorticoid de-oxy corticosterone-21-hemisuccinate crystallizes in the monoclinic space group C2, with a = 21.896(2), b = 7.596(3) and c = 14.291(3) Å, Z = 4. Ring A is a distorted half chair, ring B and C are in the chair configuration and ring D is in the 14α-half chair configuration. The ring junctions B/C and C/D are both trans. The molecule as a whole is slightly convex towards the β-side, with an angle of 18.4(2)° between the C(10) - C(19) and C(13) - C(18) vectors. In addition to packing and stacking interaction, intermolecular hydrogen bonding plays an important role in structural association. The X-ray structure determination of the title compound was undertaken to study its high binding affinity to serum protein like globulin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1265-1269 |
| Number of pages | 5 |
| Journal | Journal of Chemical Crystallography |
| Volume | 29 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1999 |
| Externally published | Yes |
Keywords
- Corticosteroid
- Crystal structure
- De-oxy corticosterone-21-hemisuccinate
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