Structure of de-oxy corticosterone-21-hemisuccinate

Raja Dey, Sandhya Roychowdhury, P. Roychowdhury

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Synthetic glucocorticoid de-oxy corticosterone-21-hemisuccinate crystallizes in the monoclinic space group C2, with a = 21.896(2), b = 7.596(3) and c = 14.291(3) Å, Z = 4. Ring A is a distorted half chair, ring B and C are in the chair configuration and ring D is in the 14α-half chair configuration. The ring junctions B/C and C/D are both trans. The molecule as a whole is slightly convex towards the β-side, with an angle of 18.4(2)° between the C(10) - C(19) and C(13) - C(18) vectors. In addition to packing and stacking interaction, intermolecular hydrogen bonding plays an important role in structural association. The X-ray structure determination of the title compound was undertaken to study its high binding affinity to serum protein like globulin.

Original languageEnglish (US)
Pages (from-to)1265-1269
Number of pages5
JournalJournal of Chemical Crystallography
Issue number12
StatePublished - Dec 1999
Externally publishedYes


  • Corticosteroid
  • Crystal structure
  • De-oxy corticosterone-21-hemisuccinate


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