TY - JOUR
T1 - Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, I(KACh)
AU - Wickman, Kevin
AU - Krapivinsky, Grigory
AU - Corey, Shawn
AU - Kennedy, Matt
AU - Nemec, Jan
AU - Medina, Igor
AU - Clapham, David E.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The muscarinic-gated atrial potassium channel I(KACh) has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of I(KACh), have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac I(KACh), the mechanism of activation of I(KACh) by G proteins, and the relevance of I(KACh) to cardiac physiology.
AB - The muscarinic-gated atrial potassium channel I(KACh) has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of I(KACh), have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac I(KACh), the mechanism of activation of I(KACh) by G proteins, and the relevance of I(KACh) to cardiac physiology.
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U2 - 10.1111/j.1749-6632.1999.tb11300.x
DO - 10.1111/j.1749-6632.1999.tb11300.x
M3 - Article
C2 - 10414308
AN - SCOPUS:0032968704
SN - 0077-8923
VL - 868
SP - 386
EP - 398
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -