Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, I(KACh)

Kevin Wickman, Grigory Krapivinsky, Shawn Corey, Matt Kennedy, Jan Nemec, Igor Medina, David E. Clapham

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The muscarinic-gated atrial potassium channel I(KACh) has been well characterized functionally, and has been an excellent model system for studying G protein/effector interactions. Complementary DNAs encoding the composite subunits of I(KACh), have been identified, allowing direct probing of structural and functional features of the channel. Here, we highlight recent approaches taken in our laboratory to determine the oligomeric structure of native cardiac I(KACh), the mechanism of activation of I(KACh) by G proteins, and the relevance of I(KACh) to cardiac physiology.

Original languageEnglish (US)
Pages (from-to)386-398
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume868
DOIs
StatePublished - 1999

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