Structure-function relationships in novel peptide dodecamers with broad-spectrum bactericidal and endotoxin-neutralizing activities

Keyphrases

• Endotoxin 100%
• Novel Peptide 100%
• Structure Function 100%
• Dodecamer 100%
• Neutralizing Activity 100%
• Lysine 33%
• Gram-negative Bacteria 33%
• Computational Modeling 33%
• Gram-positive Bacteria 33%
• Arginine 33%
• Amidation 33%
• Recurring 33%
• Bactericidal Peptides 33%
• Gram-negative 33%
• Helix 33%
• Nuclear Overhauser Effect 33%
• NMR Data 33%
• Carboxylate Group 33%
• Activity Difference 33%
• Effect-based Methods 33%
• Amphipathic Helix 33%
• Peptide Helices 33%
• Linear Peptide 33%
• Dodecapeptide 33%
• Bacterial Membrane Permeability 33%
• 33-mer 33%
• LD50 Value 33%
• Multidrug-resistant Microorganisms 33%
• SC-1 33%
• Broad-spectrum Antibacterial 33%
• Designed Peptide 33%
• Positive Bactéria 33%

Biochemistry, Genetics and Molecular Biology

• Structure Activity Relation 100%
• Peptide 100%
• Nuclear Overhauser Effect 14%
• Gram Negative Bacterium 14%
• Microorganism 14%
• C-Terminus 14%
• Amidation 14%
• Gram Positive Bacterium 14%
• Bacterial Membrane 14%
• Membrane Permeability 14%
• Computer Simulation 14%
• Lysine 14%
• Arginine 14%
• LD50 14%
• Bacterium 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Endotoxin 100%
• Peptide 100%
• Gram Positive Bacterium 14%
• Carboxylate 14%
• Gram Negative Bacterium 14%
• Antiinfective Agent 14%
• Arginine 14%
• Lysine 14%
• Microorganism 14%
• Bacterium 14%