Abstract
Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1596-1604 |
| Number of pages | 9 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 9 |
| Issue number | 14 |
| DOIs | |
| State | Published - Dec 2009 |
| Externally published | Yes |
Keywords
- Anti-tumor
- Apoptosis
- Bcl-2
- Function
- Inhibitors
- Structure
